Potential Application of Ionic Liquids in Pharmaceutical Dosage Forms for Small Molecule Drug and Vaccine Delivery System

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60076658%3A12310%2F20%3A43901237" target="_blank" >RIV/60076658:12310/20:43901237 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/61388971:_____/20:00531754

Výsledek na webu

<a href="https://journals.library.ualberta.ca/jpps/index.php/JPPS/article/view/30965/21565" target="_blank" >https://journals.library.ualberta.ca/jpps/index.php/JPPS/article/view/30965/21565</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.18433/jpps30965" target="_blank" >10.18433/jpps30965</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Potential Application of Ionic Liquids in Pharmaceutical Dosage Forms for Small Molecule Drug and Vaccine Delivery System

Popis výsledku v původním jazyce

Ionic liquids are salts in which the ions are poorly coordinated, which causes them to exist in liquid form below 100 degrees C, or at room temperature. Therefore, these are also defined as room temperature ionic liquids (RTILs). In ionic liquids, at least one ion has a delocalized charge and one component is organic, which prevents the formation of a stable solid form of crystal lattice. Physical properties of ionic liquids, such as melting point, viscosity, and solubility of starting materials and other solvents, are impacted by the substituents on the organic component and by the counterions. Many ionic liquids have even been developed to address specific synthetic problems and that is the reason these are also termed as &quot;designer solvents&quot;. Ionic liquids are considered as &quot;green solvents&quot; that exhibit several unique characteristics such as high ionic conductivity, high solvation power, thermal stability, low volatility, and recyclability. Although very useful with several advantages, ionic liquids have some limitations that include high cost and ease of recycling. Moreover, the toxicity and biodegradability of ionic liquids are not yet well understood. Nonetheless, ionic liquids can potentially be used in the field of pharmacy in drug design and formulation development. In drug or vaccine dosage formulation development, ionic liquids can be used as a solubility enhancer, permeability enhancer, stabilizer, targeted delivery inducer, stealth property provider or bioavailability enhancer. In this article we reviewed the physical properties of ionic liquids and potential application of ionic liquids in developing formulations for vaccines and small molecule drugs (A table has been added).

Název v anglickém jazyce

Potential Application of Ionic Liquids in Pharmaceutical Dosage Forms for Small Molecule Drug and Vaccine Delivery System

Popis výsledku anglicky

Ionic liquids are salts in which the ions are poorly coordinated, which causes them to exist in liquid form below 100 degrees C, or at room temperature. Therefore, these are also defined as room temperature ionic liquids (RTILs). In ionic liquids, at least one ion has a delocalized charge and one component is organic, which prevents the formation of a stable solid form of crystal lattice. Physical properties of ionic liquids, such as melting point, viscosity, and solubility of starting materials and other solvents, are impacted by the substituents on the organic component and by the counterions. Many ionic liquids have even been developed to address specific synthetic problems and that is the reason these are also termed as &quot;designer solvents&quot;. Ionic liquids are considered as &quot;green solvents&quot; that exhibit several unique characteristics such as high ionic conductivity, high solvation power, thermal stability, low volatility, and recyclability. Although very useful with several advantages, ionic liquids have some limitations that include high cost and ease of recycling. Moreover, the toxicity and biodegradability of ionic liquids are not yet well understood. Nonetheless, ionic liquids can potentially be used in the field of pharmacy in drug design and formulation development. In drug or vaccine dosage formulation development, ionic liquids can be used as a solubility enhancer, permeability enhancer, stabilizer, targeted delivery inducer, stealth property provider or bioavailability enhancer. In this article we reviewed the physical properties of ionic liquids and potential application of ionic liquids in developing formulations for vaccines and small molecule drugs (A table has been added).

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10403 - Physical chemistry

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2020

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Pharmacy and Pharmaceutical Sciences

ISSN

1482-1826

e-ISSN

—

Svazek periodika

23

Číslo periodika v rámci svazku

MAY 10 2020

Stát vydavatele periodika

CA - Kanada

Počet stran výsledku

19

Strana od-do

158-176

Kód UT WoS článku

000532236400001

EID výsledku v databázi Scopus

2-s2.0-85085158079