Diverse telomeres in trypanosomatids
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60076658%3A12310%2F21%3A43903164" target="_blank" >RIV/60076658:12310/21:43903164 - isvavai.cz</a>
Nalezeny alternativní kódy
RIV/61988987:17310/21:A2202AEC RIV/60077344:_____/21:00554492 RIV/00216208:11310/21:10430992
Výsledek na webu
<a href="https://www.cambridge.org/core/journals/parasitology/article/diverse-telomeres-in-trypanosomatids/A5F22C810DA8F772B7CB884834EB325E#" target="_blank" >https://www.cambridge.org/core/journals/parasitology/article/diverse-telomeres-in-trypanosomatids/A5F22C810DA8F772B7CB884834EB325E#</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1017/S0031182021000378" target="_blank" >10.1017/S0031182021000378</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Diverse telomeres in trypanosomatids
Popis výsledku v původním jazyce
Telomeres are the ends of linear eukaryotic chromosomes facilitating the resolution of the 'end replication and protection' problems, associated with linearity. At the nucleotide level, telomeres typically represent stretches of tandemly arranged telomeric repeats, which vary in length and sequence among different groups of organisms. Recently, a composition of the telomere-associated protein complex has been scrutinized in Trypanosoma brucei. In this work, we subjected proteins from that list to a more detailed bioinformatic analysis and delineated a core set of 20 conserved proteins putatively associated with telomeres in trypanosomatids. Out of these, two proteins (Ku70 and Ku80) are conspicuously missing in representatives of the genus Blastocrithidia, yet telomeres in these species do not appear to be affected. In this work, based on the analysis of a large set of trypanosomatids widely different in their phylogenetic position and life strategies, we demonstrated that telomeres of trypanosomatids are diverse in length, even within groups of closely related species. Our analysis showed that the expression of two proteins predicted to be associated with telomeres (those encoding telomerase and telomere-associated hypothetical protein orthologous to Tb927.6.4330) may directly affect and account for the differences in telomere length within the species of the Leishmania mexicana complex.
Název v anglickém jazyce
Diverse telomeres in trypanosomatids
Popis výsledku anglicky
Telomeres are the ends of linear eukaryotic chromosomes facilitating the resolution of the 'end replication and protection' problems, associated with linearity. At the nucleotide level, telomeres typically represent stretches of tandemly arranged telomeric repeats, which vary in length and sequence among different groups of organisms. Recently, a composition of the telomere-associated protein complex has been scrutinized in Trypanosoma brucei. In this work, we subjected proteins from that list to a more detailed bioinformatic analysis and delineated a core set of 20 conserved proteins putatively associated with telomeres in trypanosomatids. Out of these, two proteins (Ku70 and Ku80) are conspicuously missing in representatives of the genus Blastocrithidia, yet telomeres in these species do not appear to be affected. In this work, based on the analysis of a large set of trypanosomatids widely different in their phylogenetic position and life strategies, we demonstrated that telomeres of trypanosomatids are diverse in length, even within groups of closely related species. Our analysis showed that the expression of two proteins predicted to be associated with telomeres (those encoding telomerase and telomere-associated hypothetical protein orthologous to Tb927.6.4330) may directly affect and account for the differences in telomere length within the species of the Leishmania mexicana complex.
Klasifikace
Druh
J<sub>imp</sub> - Článek v periodiku v databázi Web of Science
CEP obor
—
OECD FORD obor
10606 - Microbiology
Návaznosti výsledku
Projekt
Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.
Návaznosti
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Ostatní
Rok uplatnění
2021
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Parasitology
ISSN
0031-1820
e-ISSN
—
Svazek periodika
148
Číslo periodika v rámci svazku
10
Stát vydavatele periodika
US - Spojené státy americké
Počet stran výsledku
17
Strana od-do
1254-1270
Kód UT WoS článku
000674635600015
EID výsledku v databázi Scopus
2-s2.0-85102705137