Hunting the eagle killer: A cyanobacterial neurotoxin causes vacuolar myelinopathy

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60076658%3A12310%2F21%3A43903454" target="_blank" >RIV/60076658:12310/21:43903454 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/60077344:_____/21:00552512 RIV/61388971:_____/21:00542465

Výsledek na webu

<a href="https://www.science.org/doi/10.1126/science.aax9050" target="_blank" >https://www.science.org/doi/10.1126/science.aax9050</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1126/science.aax9050" target="_blank" >10.1126/science.aax9050</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Hunting the eagle killer: A cyanobacterial neurotoxin causes vacuolar myelinopathy

Popis výsledku v původním jazyce

Vacuolar myelinopathy is a fatal neurological disease that was initially discovered during a mysterious mass mortality of bald eagles in Arkansas in the United States. The cause of this wildlife disease has eluded scientists for decades while its occurrence has continued to spread throughout freshwater reservoirs in the southeastern United States. Recent studies have demonstrated that vacuolar myelinopathy is induced by consumption of the epiphytic cyanobacterial species Aetokthonos hydrillicola growing on aquatic vegetation, primarily the invasive Hydrilla verticillata. Here, we describe the identification, biosynthetic gene cluster, and biological activity of aetokthonotoxin, a pentabrominated biindole alkaloid that is produced by the cyanobacterium A. hydrillicola. We identify this cyanobacterial neurotoxin as the causal agent of vacuolar myelinopathy and discuss environmental factors-especially bromide availability-that promote toxin production.

Název v anglickém jazyce

Hunting the eagle killer: A cyanobacterial neurotoxin causes vacuolar myelinopathy

Popis výsledku anglicky

Vacuolar myelinopathy is a fatal neurological disease that was initially discovered during a mysterious mass mortality of bald eagles in Arkansas in the United States. The cause of this wildlife disease has eluded scientists for decades while its occurrence has continued to spread throughout freshwater reservoirs in the southeastern United States. Recent studies have demonstrated that vacuolar myelinopathy is induced by consumption of the epiphytic cyanobacterial species Aetokthonos hydrillicola growing on aquatic vegetation, primarily the invasive Hydrilla verticillata. Here, we describe the identification, biosynthetic gene cluster, and biological activity of aetokthonotoxin, a pentabrominated biindole alkaloid that is produced by the cyanobacterium A. hydrillicola. We identify this cyanobacterial neurotoxin as the causal agent of vacuolar myelinopathy and discuss environmental factors-especially bromide availability-that promote toxin production.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10608 - Biochemistry and molecular biology

Projekt

<a href="/cs/project/GC19-21649J" target="_blank" >GC19-21649J: Lov na zabijáka orlů - výzkum cyanotoxinu způsobujícího ptačí vakuolární myelinopatii</a><br>

Návaznosti

S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2021

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Science

ISSN

0036-8075

e-ISSN

—

Svazek periodika

371

Číslo periodika v rámci svazku

6536

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

89

Strana od-do

"nestrankováno"

Kód UT WoS článku

000636043400031

EID výsledku v databázi Scopus

2-s2.0-85103521011