MEDETOMIDINE-KETAMINE-BUPRENORPHINE ANESTHESIA OF THE SOLITARY SUBTERRANEAN CAPE DUNE MOLE-RAT (BATHYERGUS SUILLUS) AND THE CAPE MOLE-RAT (GEORYCHUS CAPENSIS)

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60076658%3A12310%2F22%3A43904704" target="_blank" >RIV/60076658:12310/22:43904704 - isvavai.cz</a>

Výsledek na webu

<a href="https://bioone.org/journals/journal-of-zoo-and-wildlife-medicine/volume-53/issue-2/2019-0164/MEDETOMIDINEKETAMINEBUPRENORPHINE-ANESTHESIA-OF-THE-SOLITARY-SUBTERRANEAN-CAPE-DUNE-MOLE-RAT/10.1638/2019-0164.full" target="_blank" >https://bioone.org/journals/journal-of-zoo-and-wildlife-medicine/volume-53/issue-2/2019-0164/MEDETOMIDINEKETAMINEBUPRENORPHINE-ANESTHESIA-OF-THE-SOLITARY-SUBTERRANEAN-CAPE-DUNE-MOLE-RAT/10.1638/2019-0164.full</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1638/2019-0164" target="_blank" >10.1638/2019-0164</a>

Jazyk výsledku

angličtina

Název v původním jazyce

MEDETOMIDINE-KETAMINE-BUPRENORPHINE ANESTHESIA OF THE SOLITARY SUBTERRANEAN CAPE DUNE MOLE-RAT (BATHYERGUS SUILLUS) AND THE CAPE MOLE-RAT (GEORYCHUS CAPENSIS)

Popis výsledku v původním jazyce

A prospective, descriptive study was conducted to evaluate the safety and efficacy of a field-ready anesthetic drug combination of medetomidine-ketamine-buprenorphine for data logger implantation surgery or recheck in free-ranging Cape dune (Bathyergus suillus: n = 41) and Cape (Georychus capensis: n = 37) mole-rats. All anesthesia data were reported as mean (+/- standard deviation). Medetomidine-ketamine-buprenorphine doses were 0.1 (+/- 0.03), 10.6 (+/- 2.8), and 0.06 (+/- 0.03) mg/kg, respectively, for Cape dune mole-rats; and 0.2 (+/- 0.03), 19.4 (+/- 4.0), and 0.14 (+/- 0.03) mg/kg, respectively, for Cape mole-rats. Induction was calm and took 2.00 (range: 1.00-6.00) min for the Cape dune and 1.75 (range 1.25 to 8.16) min for Cape mole-rats. A surgical plane of anesthesia was achieved in most Cape dune mole-rats (92%) and Cape mole-rats (90%). The remainder required supplementation with a single intramuscular injection of ketamine (3-9 mg/kg) during surgery. Heart and respiratory rates were 149 (+/- 37) beats and 24 (+/- 8) breaths per minute, respectively, for Cape dune mole-rats and 179 (+/- 40) beats and 25 (+/- 10) and breaths per minute, respectively for Cape mole-rats. Surgical time for mole-rats ranged from 25 to 38 min. Recovery was calm and took 8.50 (range: 2.00-19.00) min for Cape dune mole-rats and 9.75 (range: 2.00-34.00) min for Cape mole-rats to recover. For recovery, atipamezole was administered intramuscularly at 0.5 (+/- 0.15) mg/kg for Cape dune mole-rats and 1 (+/- 0.15) mg/kg for Cape mole-rats. All molerats were returned to their original burrows within 48 h of recovery. The medetomidine-ketamine-buprenorphine combination induced a predictable, safe anesthesia in Cape dune and Cape mole-rats suitable for short intra-abdominal surgery. This combination is suited to in situ studies where the use of a formal surgery or laboratory is not feasible.

Název v anglickém jazyce

MEDETOMIDINE-KETAMINE-BUPRENORPHINE ANESTHESIA OF THE SOLITARY SUBTERRANEAN CAPE DUNE MOLE-RAT (BATHYERGUS SUILLUS) AND THE CAPE MOLE-RAT (GEORYCHUS CAPENSIS)

Popis výsledku anglicky

A prospective, descriptive study was conducted to evaluate the safety and efficacy of a field-ready anesthetic drug combination of medetomidine-ketamine-buprenorphine for data logger implantation surgery or recheck in free-ranging Cape dune (Bathyergus suillus: n = 41) and Cape (Georychus capensis: n = 37) mole-rats. All anesthesia data were reported as mean (+/- standard deviation). Medetomidine-ketamine-buprenorphine doses were 0.1 (+/- 0.03), 10.6 (+/- 2.8), and 0.06 (+/- 0.03) mg/kg, respectively, for Cape dune mole-rats; and 0.2 (+/- 0.03), 19.4 (+/- 4.0), and 0.14 (+/- 0.03) mg/kg, respectively, for Cape mole-rats. Induction was calm and took 2.00 (range: 1.00-6.00) min for the Cape dune and 1.75 (range 1.25 to 8.16) min for Cape mole-rats. A surgical plane of anesthesia was achieved in most Cape dune mole-rats (92%) and Cape mole-rats (90%). The remainder required supplementation with a single intramuscular injection of ketamine (3-9 mg/kg) during surgery. Heart and respiratory rates were 149 (+/- 37) beats and 24 (+/- 8) breaths per minute, respectively, for Cape dune mole-rats and 179 (+/- 40) beats and 25 (+/- 10) and breaths per minute, respectively for Cape mole-rats. Surgical time for mole-rats ranged from 25 to 38 min. Recovery was calm and took 8.50 (range: 2.00-19.00) min for Cape dune mole-rats and 9.75 (range: 2.00-34.00) min for Cape mole-rats to recover. For recovery, atipamezole was administered intramuscularly at 0.5 (+/- 0.15) mg/kg for Cape dune mole-rats and 1 (+/- 0.15) mg/kg for Cape mole-rats. All molerats were returned to their original burrows within 48 h of recovery. The medetomidine-ketamine-buprenorphine combination induced a predictable, safe anesthesia in Cape dune and Cape mole-rats suitable for short intra-abdominal surgery. This combination is suited to in situ studies where the use of a formal surgery or laboratory is not feasible.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

40301 - Veterinary science

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2022

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Zoo and Wildlife Medicine

ISSN

1042-7260

e-ISSN

1937-2825

Svazek periodika

53

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

6

Strana od-do

357-362

Kód UT WoS článku

000813462000013

EID výsledku v databázi Scopus

2-s2.0-85132710178