Socio-medical studies of individuals self-treating with helminths provide insight into clinical trial design for assessing helminth therapy

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60076658%3A12310%2F22%3A43906032" target="_blank" >RIV/60076658:12310/22:43906032 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/60077344:_____/22:00555219

Výsledek na webu

<a href="https://www.sciencedirect.com/science/article/pii/S1383576921002063?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S1383576921002063?via%3Dihub</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.parint.2021.102488" target="_blank" >10.1016/j.parint.2021.102488</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Socio-medical studies of individuals self-treating with helminths provide insight into clinical trial design for assessing helminth therapy

Popis výsledku v původním jazyce

The virtually complete loss of intestinal worms, known as helminths, from Western society has resulted in elimination of a range of helminth-induced morbidities. Unfortunately, that loss has also led to inflammation-associated deficiencies in immune function, ultimately contributing to widespread pandemics of allergies, autoimmunity, and neuropsychiatric disorders. Several socio-medical studies have examined the effects of intentional reworming, or self-treatment with helminths, on a variety of inflammation-related disorders. In this study, the latest results from ongoing socio-medical studies are described. The results point toward two important factors that appear to be overlooked in some if not most clinical trials. Specifically, (a) the method of preparation of the helminth can have a profound effect on its therapeutic efficacy, and (b) variation between individuals in the effective therapeutic dosage apparently covers a 10-fold range, regardless of the helminth used. These results highlight current limits in our understanding of the biology of both hosts and helminths, and suggest that information from self-treatment may be critical for clinical evaluation of the benefits and limits of helminth therapy. © 2021 The Authors

Název v anglickém jazyce

Socio-medical studies of individuals self-treating with helminths provide insight into clinical trial design for assessing helminth therapy

Popis výsledku anglicky

The virtually complete loss of intestinal worms, known as helminths, from Western society has resulted in elimination of a range of helminth-induced morbidities. Unfortunately, that loss has also led to inflammation-associated deficiencies in immune function, ultimately contributing to widespread pandemics of allergies, autoimmunity, and neuropsychiatric disorders. Several socio-medical studies have examined the effects of intentional reworming, or self-treatment with helminths, on a variety of inflammation-related disorders. In this study, the latest results from ongoing socio-medical studies are described. The results point toward two important factors that appear to be overlooked in some if not most clinical trials. Specifically, (a) the method of preparation of the helminth can have a profound effect on its therapeutic efficacy, and (b) variation between individuals in the effective therapeutic dosage apparently covers a 10-fold range, regardless of the helminth used. These results highlight current limits in our understanding of the biology of both hosts and helminths, and suggest that information from self-treatment may be critical for clinical evaluation of the benefits and limits of helminth therapy. © 2021 The Authors

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30311 - Medical ethics

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2022

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Parasitology International

ISSN

1383-5769

e-ISSN

—

Svazek periodika

87

Číslo periodika v rámci svazku

2022

Stát vydavatele periodika

IE - Irsko

Počet stran výsledku

10

Strana od-do

—

Kód UT WoS článku

999

EID výsledku v databázi Scopus

2-s2.0-85118558033