Telomerase as a possible key to bypass reproductive cost

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60076658%3A12310%2F23%3A43906490" target="_blank" >RIV/60076658:12310/23:43906490 - isvavai.cz</a>

Výsledek na webu

<a href="https://onlinelibrary.wiley.com/doi/10.1111/mec.16870" target="_blank" >https://onlinelibrary.wiley.com/doi/10.1111/mec.16870</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1111/mec.16870" target="_blank" >10.1111/mec.16870</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Telomerase as a possible key to bypass reproductive cost

Popis výsledku v původním jazyce

Three widely accepted assumptions are based on telomere research in human cells: (i) telomere length is a determinant of replicative ageing; (ii) telomerase activity in somatic cells supports the proliferative capacity of the cells and thus contributes to their regenerative potential and is a determinant of organismal lifespan; and (iii) the lack of telomerase activity acts as a tumour suppression mechanism. However, from a broader view, the link between telomere biology and cellular and organismal ageing, as well as tumour development, remains of debate, as I demonstrate with numerous examples of invertebrate and vertebrate species. Consequently, I propose a novel hypothesis that telomere biology, via somatic telomerase activity, reflects ageing rate from the perspective of species reproduction strategy.

Název v anglickém jazyce

Telomerase as a possible key to bypass reproductive cost

Popis výsledku anglicky

Three widely accepted assumptions are based on telomere research in human cells: (i) telomere length is a determinant of replicative ageing; (ii) telomerase activity in somatic cells supports the proliferative capacity of the cells and thus contributes to their regenerative potential and is a determinant of organismal lifespan; and (iii) the lack of telomerase activity acts as a tumour suppression mechanism. However, from a broader view, the link between telomere biology and cellular and organismal ageing, as well as tumour development, remains of debate, as I demonstrate with numerous examples of invertebrate and vertebrate species. Consequently, I propose a novel hypothesis that telomere biology, via somatic telomerase activity, reflects ageing rate from the perspective of species reproduction strategy.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10603 - Genetics and heredity (medical genetics to be 3)

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2023

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Molecular Ecology

ISSN

0962-1083

e-ISSN

1365-294X

Svazek periodika

32

Číslo periodika v rámci svazku

9

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

10

Strana od-do

2134-2143

Kód UT WoS článku

000959131600001

EID výsledku v databázi Scopus

2-s2.0-85147930051