Holobiont-holobiont interactions across host-ectoparasite systems

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60076658%3A12310%2F25%3A43910342" target="_blank" >RIV/60076658:12310/25:43910342 - isvavai.cz</a>

Výsledek na webu

<a href="https://link.springer.com/article/10.1186/s13071-025-07026-0?utm_source=getftr&utm_medium=getftr&utm_campaign=getftr_pilot&getft_integrator=clarivate" target="_blank" >https://link.springer.com/article/10.1186/s13071-025-07026-0?utm_source=getftr&utm_medium=getftr&utm_campaign=getftr_pilot&getft_integrator=clarivate</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1186/s13071-025-07026-0" target="_blank" >10.1186/s13071-025-07026-0</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Holobiont-holobiont interactions across host-ectoparasite systems

Popis výsledku v původním jazyce

Holobionts - hosts together with their resident microorganisms - provide a framework for studying life as a network of interdependent partners. Within host-ectoparasite holobionts, the dialogue between the two microbiomes offers powerful clues to ecological balance, disease dynamics and evolution. Because each holobiont is structurally and functionally compartmentalised, microbes exchanged at the interface can elicit highly local, niche-specific effects that ripple through the system. This review synthesises evidence for microbiota-to-microbiota interactions in four models: Varroa mite-honeybee, tick-vertebrate, bat fly-bat and mosquito-vertebrate pairs. In all cases, microbes move passively during feeding or contact, then colonise, replicate and modulate physiology and immunity, exerting a longer-lasting influence than transient biochemical cues. We further introduce the idea of indirect modulation, whereby abiotic or biotic factors act on a recipient holobiont through the intermediary of transferred microbes, underscoring the adaptive plasticity of holobiont networks. Bidirectional cross-talk forms self-reinforcing feedback loops that can redefine a microbe as pathogen, symbiont or immunomodulator, and tune its virulence according to context. These mechanisms shape disease transmission, resistance traits and the overall health of both partners. A deeper grasp of such cross-holobiont dynamics will pave the way for microbiota-based vaccines, targeted microbiome engineering and other innovative tools for human, veterinary and environmental health.

Název v anglickém jazyce

Holobiont-holobiont interactions across host-ectoparasite systems

Popis výsledku anglicky

Holobionts - hosts together with their resident microorganisms - provide a framework for studying life as a network of interdependent partners. Within host-ectoparasite holobionts, the dialogue between the two microbiomes offers powerful clues to ecological balance, disease dynamics and evolution. Because each holobiont is structurally and functionally compartmentalised, microbes exchanged at the interface can elicit highly local, niche-specific effects that ripple through the system. This review synthesises evidence for microbiota-to-microbiota interactions in four models: Varroa mite-honeybee, tick-vertebrate, bat fly-bat and mosquito-vertebrate pairs. In all cases, microbes move passively during feeding or contact, then colonise, replicate and modulate physiology and immunity, exerting a longer-lasting influence than transient biochemical cues. We further introduce the idea of indirect modulation, whereby abiotic or biotic factors act on a recipient holobiont through the intermediary of transferred microbes, underscoring the adaptive plasticity of holobiont networks. Bidirectional cross-talk forms self-reinforcing feedback loops that can redefine a microbe as pathogen, symbiont or immunomodulator, and tune its virulence according to context. These mechanisms shape disease transmission, resistance traits and the overall health of both partners. A deeper grasp of such cross-holobiont dynamics will pave the way for microbiota-based vaccines, targeted microbiome engineering and other innovative tools for human, veterinary and environmental health.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10606 - Microbiology

Projekt

—

Návaznosti

S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Parasites &amp; Vectors

ISSN

1756-3305

e-ISSN

1756-3305

Svazek periodika

18

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

18

Strana od-do

nestránkováno

Kód UT WoS článku

001580452200005

EID výsledku v databázi Scopus

2-s2.0-105016908481