More than one species of the naked mole-rat, a new biomedical model
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60076658%3A12310%2F25%3A43910519" target="_blank" >RIV/60076658:12310/25:43910519 - isvavai.cz</a>
Nalezeny alternativní kódy
RIV/68407700:21340/25:00388351 RIV/68407700:21670/25:00388351 RIV/00216208:11310/25:10508853
Výsledek na webu
<a href="https://www.nature.com/articles/s42003-025-09338-4" target="_blank" >https://www.nature.com/articles/s42003-025-09338-4</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1038/s42003-025-09338-4" target="_blank" >10.1038/s42003-025-09338-4</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
More than one species of the naked mole-rat, a new biomedical model
Popis výsledku v původním jazyce
The naked mole-rat Heterocephalus, a hairless, subterranean rodent from the Horn of Africa, has attracted scientific interest due to its cooperative breeding, poikilothermy, longevity, resistance to cancer, and tolerance to pain and hypoxia, among others. Genomic analyses of H. glaber, traditionally considered a single species, reveal three highly divergent lineages. One of these, identified as H. phillipsi Thomas 1885, shows deep genetic divergence (similar to 4.1 Ma) and distinct morphology, notably reduced third molars, warranting recognition as a distinct species. The remaining two lineages, previously designated as the subspecies H. g. glaber Ruppell 1842 and H. g. ansorgei Thomas 1903, diverged around 2.3 Ma and their morphological differentiation is less pronounced. Each of the lineages occupies distinct environmental conditions, with H. phillipsi inhabiting extremely harsh habitats. The finding of an unexpected diversity within this key biomedical model opens new avenues across various fields of research.
Název v anglickém jazyce
More than one species of the naked mole-rat, a new biomedical model
Popis výsledku anglicky
The naked mole-rat Heterocephalus, a hairless, subterranean rodent from the Horn of Africa, has attracted scientific interest due to its cooperative breeding, poikilothermy, longevity, resistance to cancer, and tolerance to pain and hypoxia, among others. Genomic analyses of H. glaber, traditionally considered a single species, reveal three highly divergent lineages. One of these, identified as H. phillipsi Thomas 1885, shows deep genetic divergence (similar to 4.1 Ma) and distinct morphology, notably reduced third molars, warranting recognition as a distinct species. The remaining two lineages, previously designated as the subspecies H. g. glaber Ruppell 1842 and H. g. ansorgei Thomas 1903, diverged around 2.3 Ma and their morphological differentiation is less pronounced. Each of the lineages occupies distinct environmental conditions, with H. phillipsi inhabiting extremely harsh habitats. The finding of an unexpected diversity within this key biomedical model opens new avenues across various fields of research.
Klasifikace
Druh
J<sub>imp</sub> - Článek v periodiku v databázi Web of Science
CEP obor
—
OECD FORD obor
10619 - Biodiversity conservation
Návaznosti výsledku
Projekt
<a href="/cs/project/GA20-10222S" target="_blank" >GA20-10222S: Fylogeneze, adaptace a evoluce sociality rypošovitých; modelové skupiny pro evoluční a biomedicínský výzkum</a><br>
Návaznosti
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Ostatní
Rok uplatnění
2025
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Communications Biology
ISSN
2399-3642
e-ISSN
2399-3642
Svazek periodika
9
Číslo periodika v rámci svazku
1
Stát vydavatele periodika
US - Spojené státy americké
Počet stran výsledku
11
Strana od-do
nestránkováno
Kód UT WoS článku
001663185000001
EID výsledku v databázi Scopus
2-s2.0-105027686258