Modulation of antioxidant defence system in brain of rainbow trout (Oncorhynchus mykiss) after chronic carbamazepine treatment

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60076658%3A12520%2F10%3A00009994" target="_blank" >RIV/60076658:12520/10:00009994 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Modulation of antioxidant defence system in brain of rainbow trout (Oncorhynchus mykiss) after chronic carbamazepine treatment

Popis výsledku v původním jazyce

We investigated the effect of long-term exposure to carbamazepine (CBZ) on the antioxidant system in brain tissue of rainbow trout. Fish were exposed to sublethal concentrations of CBZ (1.0 ?g/l, 0.2 mg/l or 2.0 mg/l) for 7, 21, and 42 days. Oxidative stress indices (lipid peroxidation [LPO]) and carbonyl protein [CP]) and enzymatic antioxidants (superoxide dismutase [SOD], catalase [CAT], glutathione peroxidase [GPx], and glutathione reductase [GR]) in fish brain were measured. In addition, non-enzymatic antioxidant (reduced glutathione [GSH]) was determined after 42 days exposure. Carbamazepine exposure at 0.2 mg/l led to significant increases (p<0.05) of LPO and CP after 42 days and, at 2.0 mg/l, after 21 days. Activity of the enzymatic antioxidantsSOD, CAT, and GPx in CBZ-treated groups slightly increased during the first period (7 days). However, all measured antioxidant enzymes were significantly inhibited (p<0.05) at 0.2 mg/l exposure after 42 days and after 21 days at 2.0 mg/l

Název v anglickém jazyce

Modulation of antioxidant defence system in brain of rainbow trout (Oncorhynchus mykiss) after chronic carbamazepine treatment

Popis výsledku anglicky

We investigated the effect of long-term exposure to carbamazepine (CBZ) on the antioxidant system in brain tissue of rainbow trout. Fish were exposed to sublethal concentrations of CBZ (1.0 ?g/l, 0.2 mg/l or 2.0 mg/l) for 7, 21, and 42 days. Oxidative stress indices (lipid peroxidation [LPO]) and carbonyl protein [CP]) and enzymatic antioxidants (superoxide dismutase [SOD], catalase [CAT], glutathione peroxidase [GPx], and glutathione reductase [GR]) in fish brain were measured. In addition, non-enzymatic antioxidant (reduced glutathione [GSH]) was determined after 42 days exposure. Carbamazepine exposure at 0.2 mg/l led to significant increases (p<0.05) of LPO and CP after 42 days and, at 2.0 mg/l, after 21 days. Activity of the enzymatic antioxidantsSOD, CAT, and GPx in CBZ-treated groups slightly increased during the first period (7 days). However, all measured antioxidant enzymes were significantly inhibited (p<0.05) at 0.2 mg/l exposure after 42 days and after 21 days at 2.0 mg/l

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

GL - Rybářství

OECD FORD obor

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Projekt

<a href="/cs/project/SP%2F2E7%2F229%2F07" target="_blank" >SP/2E7/229/07: Antropogenní tlaky na stav půd, vodní zdroje a vodní ekosystémy v české části mezinárodního povodí Labe</a><br>

Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2010

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Comparative Biochemistry and Physiology C - Toxicology and Pharmacology

ISSN

1532-0456

e-ISSN

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Svazek periodika

151

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

5

Strana od-do

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Kód UT WoS článku

000273152400017

EID výsledku v databázi Scopus

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