Tissue-specific bioconcentration of antidepressants in fish exposed to effluent from a municipal sewage treatment plant

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60076658%3A12520%2F14%3A43886844" target="_blank" >RIV/60076658:12520/14:43886844 - isvavai.cz</a>

Výsledek na webu

<a href="http://www.sciencedirect.com/science/article/pii/S0048969714005622" target="_blank" >http://www.sciencedirect.com/science/article/pii/S0048969714005622</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.scitotenv2014.04.052" target="_blank" >10.1016/j.scitotenv2014.04.052</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Tissue-specific bioconcentration of antidepressants in fish exposed to effluent from a municipal sewage treatment plant

Popis výsledku v původním jazyce

Tissue-specific bioconcentration of selected antidepressants was studied in rainbow trout (Oncorhynchus mykiss) exposed to undiluted effluent from a Swedish municipal sewage treatment plant for 13 days. Citalopram, sertraline and venlafaxine were found in the brains and livers of most fish, but not in blood plasma or muscle. Venlafaxine was the only drug found in plasma (3/20 fish). Fluoxetine was not detected in any fish tissue, in accordance with a low concentration in the effluent and a comparably high limit of quantification in tissues. Concentrations of citalopram, sertraline and venlafaxine in fish brain were up to 1/12, 1/8 and 1/26, respectively, of the lowest concentrations found in the brains of mammals treated with therapeutic doses. Thus, given coexposure to several antidepressants and an assumed similar potency in fish, the margin of safety for targetrelated effects in fish residing in effluent-dominated streams is relatively low. Furthermore, the non-detectable levels of

Název v anglickém jazyce

Tissue-specific bioconcentration of antidepressants in fish exposed to effluent from a municipal sewage treatment plant

Popis výsledku anglicky

Tissue-specific bioconcentration of selected antidepressants was studied in rainbow trout (Oncorhynchus mykiss) exposed to undiluted effluent from a Swedish municipal sewage treatment plant for 13 days. Citalopram, sertraline and venlafaxine were found in the brains and livers of most fish, but not in blood plasma or muscle. Venlafaxine was the only drug found in plasma (3/20 fish). Fluoxetine was not detected in any fish tissue, in accordance with a low concentration in the effluent and a comparably high limit of quantification in tissues. Concentrations of citalopram, sertraline and venlafaxine in fish brain were up to 1/12, 1/8 and 1/26, respectively, of the lowest concentrations found in the brains of mammals treated with therapeutic doses. Thus, given coexposure to several antidepressants and an assumed similar potency in fish, the margin of safety for targetrelated effects in fish residing in effluent-dominated streams is relatively low. Furthermore, the non-detectable levels of

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

DJ - Znečištění a kontrola vody

OECD FORD obor

—

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Science of the Total Environment

ISSN

0048-9697

e-ISSN

—

Svazek periodika

488

Číslo periodika v rámci svazku

Neuveden

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

5

Strana od-do

46-50

Kód UT WoS článku

000338600800005

EID výsledku v databázi Scopus

—