Physiological and molecular responses in brain of juvenile common carp (Cyprinus carpio) following exposure to tributyltin

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60076658%3A12520%2F16%3A43890374" target="_blank" >RIV/60076658:12520/16:43890374 - isvavai.cz</a>

Výsledek na webu

<a href="http://onlinelibrary.wiley.com/doi/10.1002/tox.22042/abstract;jsessionid=1B9AFF16FDAE8F7D78802C2809B9412A.f01t04" target="_blank" >http://onlinelibrary.wiley.com/doi/10.1002/tox.22042/abstract;jsessionid=1B9AFF16FDAE8F7D78802C2809B9412A.f01t04</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/tox.22042" target="_blank" >10.1002/tox.22042</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Physiological and molecular responses in brain of juvenile common carp (Cyprinus carpio) following exposure to tributyltin

Popis výsledku v původním jazyce

Tributyltin (TBT), as antifouling paints, is widely present in aquatic environment, but little is known regarding the toxicity of TBT on fish brain. In this study, the effects of exposure to TBT on the antioxidant defense system, Na+-K+-ATPase activity, neurological enzymes activity and Hsp 70 protein level in brain of juvenile common carp (Cyprinus carpio) were studied. Fish were exposed to sublethal concentrations of TBT (5, 10 and 20 g/L) for 7 days. Based on the results, with increasing concentrations of TBT, oxidative stress was apparent as reflected by the significant higher levels of oxidative indices, as well as the significant inhibition of all antioxidant enzymes activities. Besides, the activities of Acetylcholinesterase (AChE), Monoamine oxidases (MAO) and Na+-K+-ATPase were significantly inhibited after exposure to TBT with higher concentrations. In addition, the levels of Hsp 70 protein were evaluated under TBT stress with dose-depended manner. These results suggest that selected physiological responses in fish brain could be used as potential biomarkers for monitoring residual organotin compounds present in aquatic environment. (c) 2015 Wiley Periodicals, Inc. Environ Toxicol 31: 278-284, 2016.

Název v anglickém jazyce

Physiological and molecular responses in brain of juvenile common carp (Cyprinus carpio) following exposure to tributyltin

Popis výsledku anglicky

Tributyltin (TBT), as antifouling paints, is widely present in aquatic environment, but little is known regarding the toxicity of TBT on fish brain. In this study, the effects of exposure to TBT on the antioxidant defense system, Na+-K+-ATPase activity, neurological enzymes activity and Hsp 70 protein level in brain of juvenile common carp (Cyprinus carpio) were studied. Fish were exposed to sublethal concentrations of TBT (5, 10 and 20 g/L) for 7 days. Based on the results, with increasing concentrations of TBT, oxidative stress was apparent as reflected by the significant higher levels of oxidative indices, as well as the significant inhibition of all antioxidant enzymes activities. Besides, the activities of Acetylcholinesterase (AChE), Monoamine oxidases (MAO) and Na+-K+-ATPase were significantly inhibited after exposure to TBT with higher concentrations. In addition, the levels of Hsp 70 protein were evaluated under TBT stress with dose-depended manner. These results suggest that selected physiological responses in fish brain could be used as potential biomarkers for monitoring residual organotin compounds present in aquatic environment. (c) 2015 Wiley Periodicals, Inc. Environ Toxicol 31: 278-284, 2016.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

DN - Vliv životního prostředí na zdraví

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2016

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Environmental Toxicology

ISSN

1520-4081

e-ISSN

—

Svazek periodika

31

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

7

Strana od-do

278-284

Kód UT WoS článku

000370130500003

EID výsledku v databázi Scopus

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