Efficacy and toxicity of praziquantel in helminth-infected barbel (Barbus barbus L.)

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60076658%3A12520%2F18%3A43897080" target="_blank" >RIV/60076658:12520/18:43897080 - isvavai.cz</a>

Výsledek na webu

<a href="http://onlinelibrary.wiley.com/doi/10.1111/jfd.12764/full" target="_blank" >http://onlinelibrary.wiley.com/doi/10.1111/jfd.12764/full</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1111/jfd.12764" target="_blank" >10.1111/jfd.12764</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Efficacy and toxicity of praziquantel in helminth-infected barbel (Barbus barbus L.)

Popis výsledku v původním jazyce

This study evaluated efficacy and toxicity of the pyrazinoisoquinoline anthelmintic praziquantel (PZQ) in barbel infected with metacercariae of Diplostomum spathaceum and adult Pomphorhynchus laevis, and assessed antioxidant biomarkers and the lipid peroxidation response in juvenile barbel post-treatment. The estimated 96-hr LC50 of PZQ was 28.6mg/L. For evaluation of efficacy, barbel naturally infected with D.spathaceum were exposed to a 10 and 20mg/L PZQ 4-day bath treatment. Both concentrations were 100% effective against D.spathaceum and significantly (p&lt;.01) affected the activity of catalase, superoxide dismutase, glutathione reductase and glutathione-S-transferase as well as levels of reduced glutathione in liver and muscle. The efficacy of orally administered PZQ was assessed in adult barbel naturally infected with P.laevis. Fish were administered 10, 30 and 50mg/kg of body weight and examined via gut dissection after 6days. The 50mg/kg dose significantly decreased the intensity of infection. Praziquantel is a feasible bath treatment for barbel infected with D.spathaceum and has potential for oral treatment of broodfish infected with P.laevis.

Název v anglickém jazyce

Efficacy and toxicity of praziquantel in helminth-infected barbel (Barbus barbus L.)

Popis výsledku anglicky

This study evaluated efficacy and toxicity of the pyrazinoisoquinoline anthelmintic praziquantel (PZQ) in barbel infected with metacercariae of Diplostomum spathaceum and adult Pomphorhynchus laevis, and assessed antioxidant biomarkers and the lipid peroxidation response in juvenile barbel post-treatment. The estimated 96-hr LC50 of PZQ was 28.6mg/L. For evaluation of efficacy, barbel naturally infected with D.spathaceum were exposed to a 10 and 20mg/L PZQ 4-day bath treatment. Both concentrations were 100% effective against D.spathaceum and significantly (p&lt;.01) affected the activity of catalase, superoxide dismutase, glutathione reductase and glutathione-S-transferase as well as levels of reduced glutathione in liver and muscle. The efficacy of orally administered PZQ was assessed in adult barbel naturally infected with P.laevis. Fish were administered 10, 30 and 50mg/kg of body weight and examined via gut dissection after 6days. The 50mg/kg dose significantly decreased the intensity of infection. Praziquantel is a feasible bath treatment for barbel infected with D.spathaceum and has potential for oral treatment of broodfish infected with P.laevis.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

40301 - Veterinary science

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Fish Diseases

ISSN

0140-7775

e-ISSN

—

Svazek periodika

41

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

7

Strana od-do

643-649

Kód UT WoS článku

000427012300008

EID výsledku v databázi Scopus

2-s2.0-85043332219