Chronic toxicity of metolachlor OA on growth, ontogenetic development, antioxidant biomarkers and histopathology of early life stages of marbled crayfish

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60076658%3A12520%2F18%3A43897279" target="_blank" >RIV/60076658:12520/18:43897279 - isvavai.cz</a>

Výsledek na webu

<a href="https://www.sciencedirect.com/science/article/pii/S0048969718323854" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0048969718323854</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.scitotenv.2018.06.309" target="_blank" >10.1016/j.scitotenv.2018.06.309</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Chronic toxicity of metolachlor OA on growth, ontogenetic development, antioxidant biomarkers and histopathology of early life stages of marbled crayfish

Popis výsledku v původním jazyce

The metolachlor OA is a metabolite of herbicide metolachlor and s-metolachlor. The objective of the present study was to assess the effect metolachlor OA on early life stages of marbled crayfish (Procambarus virginalis). The early life stages of marbled crayfish were exposed for 45 days to three concentrations of metolachlor OA: 4.2 mu g/L (environmentally relevant concentration, E1), 42 mu g/L (E2) and 420 mu g/L (E3) under laboratory conditions. The effects were assessed on the basis of mortality, growth, ontogenetic development, behaviour, oxidative stress, antioxidant biomarkers and histopathology. Metolachlor OA caused significantly lower growth, superoxide dismutase, catalase and glutathione s-transferase activity in all tested concentrations. Metolachlor OA in higher concentrations (42 and 420 mu g/L) resulted in significantly delayed ontogenetic development, lower reduced glutathione level and lipid peroxidation. Metolachlor OA has not significant effect on behaviour (activity, total distance moved and walking speed). Histological examination revealed alteration of hepatopancreas and gills in crayfish exposed to two higher tested concentrations. Hepatopancreas reflected histomorphological structural changes of individual cell types. Changes of gills included focal hemocytic infiltration together with enlargement of intralamellar space packed with granular substance. In conclusion, chronic metolachlor OA exposure affected growth, ontogenetic development, and the antioxidant system and caused pathological changes in hepatopancreas and gills of early life stages of marbled crayfish. (C) 2018 Elsevier B.V. All rights reserved.

Název v anglickém jazyce

Chronic toxicity of metolachlor OA on growth, ontogenetic development, antioxidant biomarkers and histopathology of early life stages of marbled crayfish

Popis výsledku anglicky

The metolachlor OA is a metabolite of herbicide metolachlor and s-metolachlor. The objective of the present study was to assess the effect metolachlor OA on early life stages of marbled crayfish (Procambarus virginalis). The early life stages of marbled crayfish were exposed for 45 days to three concentrations of metolachlor OA: 4.2 mu g/L (environmentally relevant concentration, E1), 42 mu g/L (E2) and 420 mu g/L (E3) under laboratory conditions. The effects were assessed on the basis of mortality, growth, ontogenetic development, behaviour, oxidative stress, antioxidant biomarkers and histopathology. Metolachlor OA caused significantly lower growth, superoxide dismutase, catalase and glutathione s-transferase activity in all tested concentrations. Metolachlor OA in higher concentrations (42 and 420 mu g/L) resulted in significantly delayed ontogenetic development, lower reduced glutathione level and lipid peroxidation. Metolachlor OA has not significant effect on behaviour (activity, total distance moved and walking speed). Histological examination revealed alteration of hepatopancreas and gills in crayfish exposed to two higher tested concentrations. Hepatopancreas reflected histomorphological structural changes of individual cell types. Changes of gills included focal hemocytic infiltration together with enlargement of intralamellar space packed with granular substance. In conclusion, chronic metolachlor OA exposure affected growth, ontogenetic development, and the antioxidant system and caused pathological changes in hepatopancreas and gills of early life stages of marbled crayfish. (C) 2018 Elsevier B.V. All rights reserved.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10511 - Environmental sciences (social aspects to be 5.7)

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Science of the Total Environment

ISSN

0048-9697

e-ISSN

—

Svazek periodika

643

Číslo periodika v rámci svazku

12/2018

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

8

Strana od-do

1456-1463

Kód UT WoS článku

000444625900136

EID výsledku v databázi Scopus

2-s2.0-85049354464