Spatio-temporal assessment of illicit drug use at large scale: evidence from 7 years of international wastewater monitoring

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60076658%3A12520%2F20%3A43900809" target="_blank" >RIV/60076658:12520/20:43900809 - isvavai.cz</a>

Výsledek na webu

<a href="https://doi.org/10.1111/add.14767" target="_blank" >https://doi.org/10.1111/add.14767</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1111/add.14767" target="_blank" >10.1111/add.14767</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Spatio-temporal assessment of illicit drug use at large scale: evidence from 7 years of international wastewater monitoring

Popis výsledku v původním jazyce

Background and aimsWastewater-based epidemiology is an additional indicator of drug use that is gaining reliability to complement the current established panel of indicators. The aims of this study were to: (i) assess spatial and temporal trends of population-normalized mass loads of benzoylecgonine, amphetamine, methamphetamine and 3,4-methylenedioxymethamphetamine (MDMA) in raw wastewater over 7 years (2011-17); (ii) address overall drug use by estimating the average number of combined doses consumed per day in each city; and (iii) compare these with existing prevalence and seizure data. DesignAnalysis of daily raw wastewater composite samples collected over 1 week per year from 2011 to 2017. Setting and ParticipantsCatchment areas of 143 wastewater treatment plants in 120 cities in 37 countries. MeasurementsParent substances (amphetamine, methamphetamine and MDMA) and the metabolites of cocaine (benzoylecgonine) and of Delta(9)-tetrahydrocannabinol (11-nor-9-carboxy-Delta(9)-tetrahydrocannabinol) were measured in wastewater using liquid chromatography-tandem mass spectrometry. Daily mass loads (mg/day) were normalized to catchment population (mg/1000 people/day) and converted to the number of combined doses consumed per day. Spatial differences were assessed world-wide, and temporal trends were discerned at European level by comparing 2011-13 drug loads versus 2014-17 loads. FindingsBenzoylecgonine was the stimulant metabolite detected at higher loads in southern and western Europe, and amphetamine, MDMA and methamphetamine in East and North-Central Europe. In other continents, methamphetamine showed the highest levels in the United States and Australia and benzoylecgonine in South America. During the reporting period, benzoylecgonine loads increased in general across Europe, amphetamine and methamphetamine levels fluctuated and MDMA underwent an intermittent upsurge. ConclusionsThe analysis of wastewater to quantify drug loads provides near real-time drug use estimates that globally correspond to prevalence and seizure data.

Název v anglickém jazyce

Spatio-temporal assessment of illicit drug use at large scale: evidence from 7 years of international wastewater monitoring

Popis výsledku anglicky

Background and aimsWastewater-based epidemiology is an additional indicator of drug use that is gaining reliability to complement the current established panel of indicators. The aims of this study were to: (i) assess spatial and temporal trends of population-normalized mass loads of benzoylecgonine, amphetamine, methamphetamine and 3,4-methylenedioxymethamphetamine (MDMA) in raw wastewater over 7 years (2011-17); (ii) address overall drug use by estimating the average number of combined doses consumed per day in each city; and (iii) compare these with existing prevalence and seizure data. DesignAnalysis of daily raw wastewater composite samples collected over 1 week per year from 2011 to 2017. Setting and ParticipantsCatchment areas of 143 wastewater treatment plants in 120 cities in 37 countries. MeasurementsParent substances (amphetamine, methamphetamine and MDMA) and the metabolites of cocaine (benzoylecgonine) and of Delta(9)-tetrahydrocannabinol (11-nor-9-carboxy-Delta(9)-tetrahydrocannabinol) were measured in wastewater using liquid chromatography-tandem mass spectrometry. Daily mass loads (mg/day) were normalized to catchment population (mg/1000 people/day) and converted to the number of combined doses consumed per day. Spatial differences were assessed world-wide, and temporal trends were discerned at European level by comparing 2011-13 drug loads versus 2014-17 loads. FindingsBenzoylecgonine was the stimulant metabolite detected at higher loads in southern and western Europe, and amphetamine, MDMA and methamphetamine in East and North-Central Europe. In other continents, methamphetamine showed the highest levels in the United States and Australia and benzoylecgonine in South America. During the reporting period, benzoylecgonine loads increased in general across Europe, amphetamine and methamphetamine levels fluctuated and MDMA underwent an intermittent upsurge. ConclusionsThe analysis of wastewater to quantify drug loads provides near real-time drug use estimates that globally correspond to prevalence and seizure data.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30302 - Epidemiology

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2020

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Addiction

ISSN

0965-2140

e-ISSN

—

Svazek periodika

115

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

12

Strana od-do

109-120

Kód UT WoS článku

000494149500001

EID výsledku v databázi Scopus

2-s2.0-85074608360