Influence of time-dependent sampling on fish plasma levels of select pharmaceuticals and per- and polyfluoroalkyl substances (PFASs)

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60076658%3A12520%2F22%3A43904605" target="_blank" >RIV/60076658:12520/22:43904605 - isvavai.cz</a>

Výsledek na webu

<a href="https://doi.org/10.1016/j.envpol.2022.120338" target="_blank" >https://doi.org/10.1016/j.envpol.2022.120338</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.envpol.2022.120338" target="_blank" >10.1016/j.envpol.2022.120338</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Influence of time-dependent sampling on fish plasma levels of select pharmaceuticals and per- and polyfluoroalkyl substances (PFASs)

Popis výsledku v původním jazyce

Determining pharmaceutical levels in fish plasma represents an increasingly valuable approach for environ-mental assessments of pharmaceuticals. These fish plasma observations are compared to human therapeutic plasma doses because of the high evolutionary conservation of many drug targets among vertebrates. In the present study, we initially identified highly variable information regarding plasma sampling practices in the literature and then tested the hypothesis that fish plasma levels of selected pharmaceuticals and per-and pol-yfluoroalkyl substances (PFASs) would not change with time to process samples from the field. After common carp were placed in a wastewater-fed pond for one month, we immediately sampled fish plasma nonlethally in the field or after transferring fish to clean water and held them under these conditions for either 3 or 20 h. We then quantitated pharmaceuticals in water, and pharmaceuticals and PFASs in plasma by LC-MSMS. Whereas plasma levels of most pharmaceuticals decreased even after 3 h that fish spent in clean water, plasma concen-trations of the PFASs examined here remained stable over 20 h. Collectively, our examination of these time -dependent sampling approaches and associated findings highlight the importance of appropriate and consis-tent sampling for bioaccumulation studies, biomonitoring activities, and aquaculture product safety evaluations.

Název v anglickém jazyce

Influence of time-dependent sampling on fish plasma levels of select pharmaceuticals and per- and polyfluoroalkyl substances (PFASs)

Popis výsledku anglicky

Determining pharmaceutical levels in fish plasma represents an increasingly valuable approach for environ-mental assessments of pharmaceuticals. These fish plasma observations are compared to human therapeutic plasma doses because of the high evolutionary conservation of many drug targets among vertebrates. In the present study, we initially identified highly variable information regarding plasma sampling practices in the literature and then tested the hypothesis that fish plasma levels of selected pharmaceuticals and per-and pol-yfluoroalkyl substances (PFASs) would not change with time to process samples from the field. After common carp were placed in a wastewater-fed pond for one month, we immediately sampled fish plasma nonlethally in the field or after transferring fish to clean water and held them under these conditions for either 3 or 20 h. We then quantitated pharmaceuticals in water, and pharmaceuticals and PFASs in plasma by LC-MSMS. Whereas plasma levels of most pharmaceuticals decreased even after 3 h that fish spent in clean water, plasma concen-trations of the PFASs examined here remained stable over 20 h. Collectively, our examination of these time -dependent sampling approaches and associated findings highlight the importance of appropriate and consis-tent sampling for bioaccumulation studies, biomonitoring activities, and aquaculture product safety evaluations.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10511 - Environmental sciences (social aspects to be 5.7)

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2022

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Environmental Pollution

ISSN

0269-7491

e-ISSN

1873-6424

Svazek periodika

315

Číslo periodika v rámci svazku

neuvedeno

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

6

Strana od-do

nestrankovano

Kód UT WoS článku

000870025800001

EID výsledku v databázi Scopus

2-s2.0-85139736767