Environmental hazards from pollution of antibiotics and resistance-driving chemicals in an urban river network from Malawi

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60076658%3A12520%2F25%3A43910144" target="_blank" >RIV/60076658:12520/25:43910144 - isvavai.cz</a>

Výsledek na webu

<a href="https://doi.org/10.1101/2025.04.15.25325896" target="_blank" >https://doi.org/10.1101/2025.04.15.25325896</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1038/s44259-025-00149-5" target="_blank" >10.1038/s44259-025-00149-5</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Environmental hazards from pollution of antibiotics and resistance-driving chemicals in an urban river network from Malawi

Popis výsledku v původním jazyce

African communities have a high prevalence of antimicrobial-resistant bacterial carriage, alongside high levels of antibiotic usage and environmental pollution. Limited access to water, sanitation and hygiene infrastructure and wastewater treatment facilities enables the dissemination of resistant bacteria, antimicrobials and antibiotic resistance-driving chemicals (ARDCs) into local rivers. Few data exist quantifying the chemical drivers of antimicrobial resistance (AMR) in urban aquatic environments from African settings. In this longitudinal surveillance study, we investigated an urban river network in Blantyre, Malawi over a continuous 12-month period, identifying a broad-range of chemical pollutants, including antibiotics, common pharmaceuticals, agricultural and industrial chemicals and heavy metals. Antimicrobial concentrations were found at levels selective for AMR and ARDCs exhibited seasonal variations, indicating that deficient sanitation infrastructure and anthropogenic factors result in high antibiotic and ARDC levels entering the river systems, which serve as an important ecological niche for the acquisition, maintenance and transmission of AMR.

Název v anglickém jazyce

Environmental hazards from pollution of antibiotics and resistance-driving chemicals in an urban river network from Malawi

Popis výsledku anglicky

African communities have a high prevalence of antimicrobial-resistant bacterial carriage, alongside high levels of antibiotic usage and environmental pollution. Limited access to water, sanitation and hygiene infrastructure and wastewater treatment facilities enables the dissemination of resistant bacteria, antimicrobials and antibiotic resistance-driving chemicals (ARDCs) into local rivers. Few data exist quantifying the chemical drivers of antimicrobial resistance (AMR) in urban aquatic environments from African settings. In this longitudinal surveillance study, we investigated an urban river network in Blantyre, Malawi over a continuous 12-month period, identifying a broad-range of chemical pollutants, including antibiotics, common pharmaceuticals, agricultural and industrial chemicals and heavy metals. Antimicrobial concentrations were found at levels selective for AMR and ARDCs exhibited seasonal variations, indicating that deficient sanitation infrastructure and anthropogenic factors result in high antibiotic and ARDC levels entering the river systems, which serve as an important ecological niche for the acquisition, maintenance and transmission of AMR.

Druh

J_ost - Ostatní články v recenzovaných periodicích

CEP obor

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OECD FORD obor

10511 - Environmental sciences (social aspects to be 5.7)

Projekt

<a href="/cs/project/GX20-04676X" target="_blank" >GX20-04676X: Holistická charakterizace expozice a potenciálních účinků komplexních směsí chemických látek ve vodním prostředí</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

NPJ Antimicrobials and Resistance

ISSN

2731-8745

e-ISSN

2731-8745

Svazek periodika

3

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

14

Strana od-do

nestránkováno

Kód UT WoS článku

001636075600001

EID výsledku v databázi Scopus

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