Indukce cytochromu P450 v rybách - biochemický marker kontaminace řeky Labe

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60076658%3A12610%2F04%3A00005827" target="_blank" >RIV/60076658:12610/04:00005827 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Cytochrome P450 induction in fish as a biochemical marker of Labe river contamination

Popis výsledku v původním jazyce

Cytochrome P450 is a significant biochemical marker of Labe river contamination for assessment of surface water contamination by a large scale of industrial pollutants. Cytochrome P450 is a mono-oxygenase enzymatic complex occuring practically in all live organisms, which is responsible for biotransformation of endogenous substances and xenobiotics. The activity of some pollutants causes its induction that may last even over period of several months. Its concentration is determined spectrophorometrically from fish liver samples. The increased cytochrome P450 activity is linked to increased activation of further enzymes. In fish there occurs an increase of ethoxyresorufin-O-deethylase, which is also utilized for an assessment of burdens of water ecosystems. During monitoring programme of river Labe pollution the samples from 10 differently polluted locations were collected to determine their concentration of the biochemical markers i.e. cytochrome P450 and ethoxyresorufin-O-deethylase.

Název v anglickém jazyce

Cytochrome P450 induction in fish as a biochemical marker of Labe river contamination

Popis výsledku anglicky

Cytochrome P450 is a significant biochemical marker of Labe river contamination for assessment of surface water contamination by a large scale of industrial pollutants. Cytochrome P450 is a mono-oxygenase enzymatic complex occuring practically in all live organisms, which is responsible for biotransformation of endogenous substances and xenobiotics. The activity of some pollutants causes its induction that may last even over period of several months. Its concentration is determined spectrophorometrically from fish liver samples. The increased cytochrome P450 activity is linked to increased activation of further enzymes. In fish there occurs an increase of ethoxyresorufin-O-deethylase, which is also utilized for an assessment of burdens of water ecosystems. During monitoring programme of river Labe pollution the samples from 10 differently polluted locations were collected to determine their concentration of the biochemical markers i.e. cytochrome P450 and ethoxyresorufin-O-deethylase.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

DN - Vliv životního prostředí na zdraví

OECD FORD obor

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Projekt

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Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2004

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Toxicology and Applied Pharmacology

ISSN

0041-008X

e-ISSN

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Svazek periodika

197

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

1

Strana od-do

189

Kód UT WoS článku

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EID výsledku v databázi Scopus

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