Vliv extraktu slinných žláz klíštěte Ixodes ricinus na in vivo proliferaci spirochéty Borrelia burgdorferi sensu stricto

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F06%3A00048903" target="_blank" >RIV/60077344:_____/06:00048903 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/60076658:12310/06:00006839

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Effect of salivary gland extract from Ixodes ricinus ticks on the proliferation of Borrelia burgdorferi sensu stricto in vivo

Popis výsledku v původním jazyce

Hard-bodied tick Ixodes ricinus is an important vector of Lyme disease spirochete Borrelia burgdorferi sensu lato. Feeding of ixodid ticks extends over a number of days and it provides an opportunity for vector-host immune interaction. The interplay includes host immune defense against tick feeding as well as modulation of host immune response induced by tick feeding. Recently, increasing evidence supports the idea that tick-borne pathogens take advantage of immunomodulatory factors in tick saliva to facilitate their transmission. We have examined effect of salivary gland extract from I. ricinus on the spirochete proliferation during mouse infection, to test existence of saliva activated transmission (SAT). First direct evidence of B. burgdorferi SAT was demonstrated using real-time PCR on day 1 post infection, when a significant increase in spirochetes was found in mouse tissues, compared with control group.

Název v anglickém jazyce

Effect of salivary gland extract from Ixodes ricinus ticks on the proliferation of Borrelia burgdorferi sensu stricto in vivo

Popis výsledku anglicky

Hard-bodied tick Ixodes ricinus is an important vector of Lyme disease spirochete Borrelia burgdorferi sensu lato. Feeding of ixodid ticks extends over a number of days and it provides an opportunity for vector-host immune interaction. The interplay includes host immune defense against tick feeding as well as modulation of host immune response induced by tick feeding. Recently, increasing evidence supports the idea that tick-borne pathogens take advantage of immunomodulatory factors in tick saliva to facilitate their transmission. We have examined effect of salivary gland extract from I. ricinus on the spirochete proliferation during mouse infection, to test existence of saliva activated transmission (SAT). First direct evidence of B. burgdorferi SAT was demonstrated using real-time PCR on day 1 post infection, when a significant increase in spirochetes was found in mouse tissues, compared with control group.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EC - Imunologie

OECD FORD obor

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Projekt

<a href="/cs/project/GA524%2F05%2F0811" target="_blank" >GA524/05/0811: Přenos významných patogenů aktivovaný klíštěcími slinami</a><br>

Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2006

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Folia Parasitologica

ISSN

0015-5683

e-ISSN

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Svazek periodika

53

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

6

Strana od-do

153-158

Kód UT WoS článku

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EID výsledku v databázi Scopus

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