Tick-borne encephalitis virus infection of cultured mouse macrophages

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F09%3A00334900" target="_blank" >RIV/60077344:_____/09:00334900 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/60076658:12310/09:00010477

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Tick-borne encephalitis virus infection of cultured mouse macrophages

Popis výsledku v původním jazyce

The interactions of tick-borne encephalitis virus (TBEV) with mouse macrophages were studied at electron microscopic level. The macrophages were sensitive to infection with TBEV strain Hypr (a highly neuroinvasive and neurovirulent strain for laboratorymice). However, these macrophage cells remained morphologically inactivated. Viral particles were located mainly in the ER. No virus production was observed in cells infected with the attenuated, non-neuroinvasive TBEV strain 263. In this case, the infection led to a clear morphological activation of the macrophages. The virus replication process in mouse macrophage cells might be different from that in other mammalian cell lines. Moreover, different TBEV strains exhibited a different interaction with the host macrophages. The inability of strain 263 to replicate in mouse macrophages as the first site of significant viral replication in vivo could be associated with the inability of this strain to establish a serious infection in mice.

Název v anglickém jazyce

Tick-borne encephalitis virus infection of cultured mouse macrophages

Popis výsledku anglicky

The interactions of tick-borne encephalitis virus (TBEV) with mouse macrophages were studied at electron microscopic level. The macrophages were sensitive to infection with TBEV strain Hypr (a highly neuroinvasive and neurovirulent strain for laboratorymice). However, these macrophage cells remained morphologically inactivated. Viral particles were located mainly in the ER. No virus production was observed in cells infected with the attenuated, non-neuroinvasive TBEV strain 263. In this case, the infection led to a clear morphological activation of the macrophages. The virus replication process in mouse macrophage cells might be different from that in other mammalian cell lines. Moreover, different TBEV strains exhibited a different interaction with the host macrophages. The inability of strain 263 to replicate in mouse macrophages as the first site of significant viral replication in vivo could be associated with the inability of this strain to establish a serious infection in mice.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

GJ - Choroby a škůdci zvířat, veterinární medicina

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2009

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Intervirology

ISSN

0300-5526

e-ISSN

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Svazek periodika

52

Číslo periodika v rámci svazku

5

Stát vydavatele periodika

SZ - Svazijské království

Počet stran výsledku

8

Strana od-do

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Kód UT WoS článku

000269788600008

EID výsledku v databázi Scopus

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