Tick saliva affects both proliferation and distribution of Borrelia burgdorferi spirochetes in mouse organs and increases transmission of spirochetes to ticks

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F09%3A00334910" target="_blank" >RIV/60077344:_____/09:00334910 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Tick saliva affects both proliferation and distribution of Borrelia burgdorferi spirochetes in mouse organs and increases transmission of spirochetes to ticks

Popis výsledku v původním jazyce

The influence of the feeding of uninfected Ixodes ricinus nymphs on the proliferation and distribution of Borrelia burgdorferi spirochetes was compared with the effect of coinoculated saliva or salivary gland extract (SGE). SGE significantly increased spirochete numbers in the skin 4 and 6 dpi, but decreased bacterial load in the heart compared to control animals. The inoculation of tick saliva increased spirochete load in the urinary bladder 6 dpi, while the number of spirochetes in the heart declined.The nymph feeding raised spirochete load in the bladder 4 and 6 dpi. On day 6, the number of spirochetes in the heart was significantly lower than in controls. The prevalence of spirochetes in ticks infected by feeding on mice was 10 higher when the mice were infected with spirochetes and saliva or SGE, in comparison with spirochetes alone. The presence of SGE in the inoculum increased spirochete burden per tick from 0 to almost 28000.

Název v anglickém jazyce

Tick saliva affects both proliferation and distribution of Borrelia burgdorferi spirochetes in mouse organs and increases transmission of spirochetes to ticks

Popis výsledku anglicky

The influence of the feeding of uninfected Ixodes ricinus nymphs on the proliferation and distribution of Borrelia burgdorferi spirochetes was compared with the effect of coinoculated saliva or salivary gland extract (SGE). SGE significantly increased spirochete numbers in the skin 4 and 6 dpi, but decreased bacterial load in the heart compared to control animals. The inoculation of tick saliva increased spirochete load in the urinary bladder 6 dpi, while the number of spirochetes in the heart declined.The nymph feeding raised spirochete load in the bladder 4 and 6 dpi. On day 6, the number of spirochetes in the heart was significantly lower than in controls. The prevalence of spirochetes in ticks infected by feeding on mice was 10 higher when the mice were infected with spirochetes and saliva or SGE, in comparison with spirochetes alone. The presence of SGE in the inoculum increased spirochete burden per tick from 0 to almost 28000.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EC - Imunologie

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2009

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

International Journal of Medical Microbiology

ISSN

1438-4221

e-ISSN

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Svazek periodika

299

Číslo periodika v rámci svazku

5

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

8

Strana od-do

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Kód UT WoS článku

000267688600007

EID výsledku v databázi Scopus

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