The nuclear receptor NHR-25 cooperates with the Wnt/ .beta.-catenin asymmetry pathway to control differentiation of the T seam cell in C. elegans

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F09%3A00334921" target="_blank" >RIV/60077344:_____/09:00334921 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/60076658:12310/09:00010453

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

The nuclear receptor NHR-25 cooperates with the Wnt/ .beta.-catenin asymmetry pathway to control differentiation of the T seam cell in C. elegans

Popis výsledku v původním jazyce

Asymmetric cell divisions produce cells with distinct developmental fates, thus allowing differentiation of various tissues. Caenorhabditis elegans is extensively used to study cell fate determination, since its development relies heavily on asymmetric cell divisions. Differentiation of the epidermal cell T depends on its proper polarity that is established by the Wnt/.beta.-catenin asymmetry pathway. We show that the asymmetry of T cell division requires NHR-25, an evolutionarily conserved nuclear receptor. NHR-25 ensures the neural fate of the T cell lineage in cooperation with the Wnt/.beta.-catenin signaling. Loss of NHR-25 enhances the impact of mutated effectors of this pathway, POP-1/TCF and SYS-1/.beta.-catenin, on the T cell polarity, while itsuppresses the effect of the same mutations on asymmetric division of the somatic gonad precursor cells. Therefore, our findings define NHR-25 as a versatile modulator of Wnt/.beta.-catenin signaling to govern correct cell fate decision.

Název v anglickém jazyce

The nuclear receptor NHR-25 cooperates with the Wnt/ .beta.-catenin asymmetry pathway to control differentiation of the T seam cell in C. elegans

Popis výsledku anglicky

Asymmetric cell divisions produce cells with distinct developmental fates, thus allowing differentiation of various tissues. Caenorhabditis elegans is extensively used to study cell fate determination, since its development relies heavily on asymmetric cell divisions. Differentiation of the epidermal cell T depends on its proper polarity that is established by the Wnt/.beta.-catenin asymmetry pathway. We show that the asymmetry of T cell division requires NHR-25, an evolutionarily conserved nuclear receptor. NHR-25 ensures the neural fate of the T cell lineage in cooperation with the Wnt/.beta.-catenin signaling. Loss of NHR-25 enhances the impact of mutated effectors of this pathway, POP-1/TCF and SYS-1/.beta.-catenin, on the T cell polarity, while itsuppresses the effect of the same mutations on asymmetric division of the somatic gonad precursor cells. Therefore, our findings define NHR-25 as a versatile modulator of Wnt/.beta.-catenin signaling to govern correct cell fate decision.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EB - Genetika a molekulární biologie

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2009

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Cell Science

ISSN

0021-9533

e-ISSN

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Svazek periodika

122

Číslo periodika v rámci svazku

17

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

10

Strana od-do

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Kód UT WoS článku

000269122000005

EID výsledku v databázi Scopus

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