Interaction between Drosophila bZIP proteins Atf3 and Jun prevents replacement of epithelial cells during metamorphosis

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F10%3A00338123" target="_blank" >RIV/60077344:_____/10:00338123 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Interaction between Drosophila bZIP proteins Atf3 and Jun prevents replacement of epithelial cells during metamorphosis

Popis výsledku v původním jazyce

Animal development involves movements and fusions of epithelia. During metamorphosis of Drosophila, the precursor cells of abdominal epidermis (histoblasts) divide and migrate while replacing larval epidermal cells (LECs), which must depart from the epithelium to allow histoblast fusion and formation of the adult epidermis. Regulation of this morphogenetic cell replacement is unclear. We have found that temporally misregulated activity of the transcription factor Atf3 prevents LEC extrusion by interfering with the Rho signaling, leading to increased adhesiveness of LECs that consequently obstruct the closure of the adult abdominal epithelium. To elicit this effect, Atf3 requires its binding partner Jun. Although dimerization between the two important regulatory bZIP proteins has been well-established in mammalian cell lines, our data for the first time demonstrate a developmental function for the Jun-Atf3 complex in vivo.

Název v anglickém jazyce

Interaction between Drosophila bZIP proteins Atf3 and Jun prevents replacement of epithelial cells during metamorphosis

Popis výsledku anglicky

Animal development involves movements and fusions of epithelia. During metamorphosis of Drosophila, the precursor cells of abdominal epidermis (histoblasts) divide and migrate while replacing larval epidermal cells (LECs), which must depart from the epithelium to allow histoblast fusion and formation of the adult epidermis. Regulation of this morphogenetic cell replacement is unclear. We have found that temporally misregulated activity of the transcription factor Atf3 prevents LEC extrusion by interfering with the Rho signaling, leading to increased adhesiveness of LECs that consequently obstruct the closure of the adult abdominal epithelium. To elicit this effect, Atf3 requires its binding partner Jun. Although dimerization between the two important regulatory bZIP proteins has been well-established in mammalian cell lines, our data for the first time demonstrate a developmental function for the Jun-Atf3 complex in vivo.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EA - Morfologické obory a cytologie

OECD FORD obor

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Projekt

<a href="/cs/project/2B06129" target="_blank" >2B06129: MODELOVÉ ORGANISMY JAKO KLÍČ K POCHOPENÍ FUNKCE GENŮ NEZBYTNÝCH PRO ZDRAVÍ ČLOVĚKA</a><br>

Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2010

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Development

ISSN

0950-1991

e-ISSN

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Svazek periodika

137

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

10

Strana od-do

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Kód UT WoS článku

000272977200018

EID výsledku v databázi Scopus

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