Cathepsins B1 and B2 of Trichobilharzia spp., bird schistosomes causing cercarial dermatitis

Kód výsledku v IS VaVaI

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Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Cathepsins B1 and B2 of Trichobilharzia spp., bird schistosomes causing cercarial dermatitis

Popis výsledku v původním jazyce

Trichobilharzia regenti and T. szidati are schistosomes that infect birds. Although T. regenti/T. szidati can only complete their life cycle in specific bird hosts, their larvae -cercariae are able to penetrate, transform and then migrate as schistosomula in nonspecific hosts. Peptidases are among the key molecules produced by these schistosomes that enable parasite invasion and survival within the host. These enzymes are indispensable bio catalysts in a number of basal biological processes and host parasite interactions, e.g., tissue invasion/migration, nutrition and immune evasion. Similar biochemical and functional characteristics were observed for cathepsins B1 and B2 in bird schistosomes and also for their homologs in human schistosomes (Schistosoma mansoni, S. japonicum). Therefore, data obtained in the research of bird schistosomes can also be exploited for the control of human schistosomes such as the search for targets of novel chemotherapeutic drugs and vaccines.

Název v anglickém jazyce

Cathepsins B1 and B2 of Trichobilharzia spp., bird schistosomes causing cercarial dermatitis

Popis výsledku anglicky

Trichobilharzia regenti and T. szidati are schistosomes that infect birds. Although T. regenti/T. szidati can only complete their life cycle in specific bird hosts, their larvae -cercariae are able to penetrate, transform and then migrate as schistosomula in nonspecific hosts. Peptidases are among the key molecules produced by these schistosomes that enable parasite invasion and survival within the host. These enzymes are indispensable bio catalysts in a number of basal biological processes and host parasite interactions, e.g., tissue invasion/migration, nutrition and immune evasion. Similar biochemical and functional characteristics were observed for cathepsins B1 and B2 in bird schistosomes and also for their homologs in human schistosomes (Schistosoma mansoni, S. japonicum). Therefore, data obtained in the research of bird schistosomes can also be exploited for the control of human schistosomes such as the search for targets of novel chemotherapeutic drugs and vaccines.

Druh

C - Kapitola v odborné knize

CEP obor

GJ - Choroby a škůdci zvířat, veterinární medicina

OECD FORD obor

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Projekt

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Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2011

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název knihy nebo sborníku

Cysteine Proteases of Pathogenic Organisms Cysteine Proteases of Pathogenic Organisms

ISBN

978-1-4419-8413-5

Počet stran výsledku

19

Strana od-do

136-154

Počet stran knihy

222

Název nakladatele

SPRINGER-VERLAG BERLIN, HEIDELBERGER PLATZ 3, D-14197

Místo vydání

BERLIN

Kód UT WoS kapitoly

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