An invertebrate [hydroxyproline]-modified neuropeptide: further evidence for a close evolutionary relationship between insect adipokinetic hormone and mammalian gonadotropin hormone family
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F11%3A00368706" target="_blank" >RIV/60077344:_____/11:00368706 - isvavai.cz</a>
Výsledek na webu
<a href="http://dx.doi.org/10.1016/j.bbrc.2011.09.127" target="_blank" >http://dx.doi.org/10.1016/j.bbrc.2011.09.127</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.bbrc.2011.09.127" target="_blank" >10.1016/j.bbrc.2011.09.127</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
An invertebrate [hydroxyproline]-modified neuropeptide: further evidence for a close evolutionary relationship between insect adipokinetic hormone and mammalian gonadotropin hormone family
Popis výsledku v původním jazyce
An octapeptide of the adipokinetic hormone (AKH) peptide family is identified in corpora cardiaca of the stink bug, Nezara viridula. This is the second AKH in N. viridula and it has a hydroxyproline residue at position 6, whereas the major AKH (known asPanbo-RPCH) has Pro as the sixth amino acid residue. Various extraction procedures were followed to ascertain whether the hydroxylation is an artefact of extraction, or whether it is due to a true post-translational modification at the prohormone level.The proline hydroxylation is unique for invertebrate neuropeptides, while it has been described in the vertebrate gonadotropin-releasing hormone (GnRH). The current finding is another piece of evidence that AKH and GnRH form a peptide superfamily and areclosely related evolutionarily. Biologically, [Hyp6]-Panbo-RPCH is active in vivo as an AKH, causing hyperlipaemia in the stink bug at low doses, indicating that it is an endogenous, mature and functional hormone in this insect species.
Název v anglickém jazyce
An invertebrate [hydroxyproline]-modified neuropeptide: further evidence for a close evolutionary relationship between insect adipokinetic hormone and mammalian gonadotropin hormone family
Popis výsledku anglicky
An octapeptide of the adipokinetic hormone (AKH) peptide family is identified in corpora cardiaca of the stink bug, Nezara viridula. This is the second AKH in N. viridula and it has a hydroxyproline residue at position 6, whereas the major AKH (known asPanbo-RPCH) has Pro as the sixth amino acid residue. Various extraction procedures were followed to ascertain whether the hydroxylation is an artefact of extraction, or whether it is due to a true post-translational modification at the prohormone level.The proline hydroxylation is unique for invertebrate neuropeptides, while it has been described in the vertebrate gonadotropin-releasing hormone (GnRH). The current finding is another piece of evidence that AKH and GnRH form a peptide superfamily and areclosely related evolutionarily. Biologically, [Hyp6]-Panbo-RPCH is active in vivo as an AKH, causing hyperlipaemia in the stink bug at low doses, indicating that it is an endogenous, mature and functional hormone in this insect species.
Klasifikace
Druh
J<sub>x</sub> - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
CEP obor
ED - Fyziologie
OECD FORD obor
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Návaznosti výsledku
Projekt
<a href="/cs/project/GAP206%2F10%2F2401" target="_blank" >GAP206/10/2401: Profilování metabolitů a potenciálních biomarkerů v moči pacientů s diagnostikovanou rakovinou prsu nebo prostaty</a><br>
Návaznosti
Z - Vyzkumny zamer (s odkazem do CEZ)
Ostatní
Rok uplatnění
2011
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Biochemical and Biophysical Research Communications
ISSN
0006-291X
e-ISSN
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Svazek periodika
414
Číslo periodika v rámci svazku
3
Stát vydavatele periodika
US - Spojené státy americké
Počet stran výsledku
6
Strana od-do
592-597
Kód UT WoS článku
000298519500026
EID výsledku v databázi Scopus
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