A myth about the ?potent cardiostimulating? action of insect neuropeptides has been unfounded

Kód výsledku v IS VaVaI

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Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

A myth about the ?potent cardiostimulating? action of insect neuropeptides has been unfounded

Popis výsledku v původním jazyce

Chemists and biochemists isolating or synthesizing insect neuropeptides used to create a myth about ?potent cardiostimulating properties of these peptides. The myth was motivated by a tendency to gain professional importance and scientific merit of theirwork. Crucial arguments in favour of the idea were obtained by simple, largely nonspecific, in vitro bioassays performed on isolated hearts of cockroaches in saline. These assays gave positive responses to a wide range of low molecular compounds as wellas to most peptides tested. Our attempts to solve this problem started by development of new touch-free electrocardiographic methods for monitoring the heartbeat of unrestrained insects. Extensive in vivo recordings revealed that the tentatively ?cardioactive neuropeptides had no cardiostimulating activity under physiological conditions. Intimate similarities appeared between regulation of insect and human hearts. Accordingly, a cardioactive peptide does not exist in human medicine as w

Název v anglickém jazyce

A myth about the ?potent cardiostimulating? action of insect neuropeptides has been unfounded

Popis výsledku anglicky

Chemists and biochemists isolating or synthesizing insect neuropeptides used to create a myth about ?potent cardiostimulating properties of these peptides. The myth was motivated by a tendency to gain professional importance and scientific merit of theirwork. Crucial arguments in favour of the idea were obtained by simple, largely nonspecific, in vitro bioassays performed on isolated hearts of cockroaches in saline. These assays gave positive responses to a wide range of low molecular compounds as wellas to most peptides tested. Our attempts to solve this problem started by development of new touch-free electrocardiographic methods for monitoring the heartbeat of unrestrained insects. Extensive in vivo recordings revealed that the tentatively ?cardioactive neuropeptides had no cardiostimulating activity under physiological conditions. Intimate similarities appeared between regulation of insect and human hearts. Accordingly, a cardioactive peptide does not exist in human medicine as w

Druh

D - Stať ve sborníku

CEP obor

ED - Fyziologie

OECD FORD obor

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Projekt

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Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2011

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

Collection Symposium Series

ISBN

978-80-86241-44-9

ISSN

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e-ISSN

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Počet stran výsledku

5

Strana od-do

130-135

Název nakladatele

Institute of Organic Chemistry and Biochemistry

Místo vydání

Praha

Místo konání akce

Praha

Datum konání akce

27. 4. 2011

Typ akce podle státní příslušnosti

EUR - Evropská akce

Kód UT WoS článku

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