Global gene expression changes in human urothelial cells exposed to low-level monomethylarsonous acid

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F12%3A00377194" target="_blank" >RIV/60077344:_____/12:00377194 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.tox.2011.11.002" target="_blank" >http://dx.doi.org/10.1016/j.tox.2011.11.002</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.tox.2011.11.002" target="_blank" >10.1016/j.tox.2011.11.002</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Global gene expression changes in human urothelial cells exposed to low-level monomethylarsonous acid

Popis výsledku v původním jazyce

Bladder cancer has been associated with chronic arsenic exposure. Monomethylarsonous acid [MMA(III)] is a metabolite of inorganic arsenic and has been shown to transform an immortalized urothelial cell line (UROtsa). MMA(III) was used as a model arsenical to examine the mechanisms of arsenical-induced transformation of urothelium. A microarray analysis was performed to assess the transcriptional changes in UROtsa. The analysis revealed only minor changes in gene expression at 1 and 2 months of exposure,contrasting with substantial changes observed at 3 months of exposure. The gene expression changes at 3 months were analyzed showing distinct alterations in biological processes and pathways such as a response to oxidative stress, enhanced cell proliferation, anti-apoptosis, MAPK signaling, as well as inflammation.

Název v anglickém jazyce

Global gene expression changes in human urothelial cells exposed to low-level monomethylarsonous acid

Popis výsledku anglicky

Bladder cancer has been associated with chronic arsenic exposure. Monomethylarsonous acid [MMA(III)] is a metabolite of inorganic arsenic and has been shown to transform an immortalized urothelial cell line (UROtsa). MMA(III) was used as a model arsenical to examine the mechanisms of arsenical-induced transformation of urothelium. A microarray analysis was performed to assess the transcriptional changes in UROtsa. The analysis revealed only minor changes in gene expression at 1 and 2 months of exposure,contrasting with substantial changes observed at 3 months of exposure. The gene expression changes at 3 months were analyzed showing distinct alterations in biological processes and pathways such as a response to oxidative stress, enhanced cell proliferation, anti-apoptosis, MAPK signaling, as well as inflammation.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EB - Genetika a molekulární biologie

OECD FORD obor

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Projekt

—

Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2012

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Toxicology

ISSN

0300-483X

e-ISSN

—

Svazek periodika

291

Číslo periodika v rámci svazku

1-3

Stát vydavatele periodika

IE - Irsko

Počet stran výsledku

11

Strana od-do

102-112

Kód UT WoS článku

000300752800013

EID výsledku v databázi Scopus

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