Tick saliva-mediated immunomodulation of the vertebrate host

Kód výsledku v IS VaVaI

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Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Tick saliva-mediated immunomodulation of the vertebrate host

Popis výsledku v původním jazyce

The feeding period of hard ticks often exceeds one week and makes tick infestation a considerable intervention to host physiology. A broad range of inflammatory and immune reactions take place locally at the feeding site as well as systemically within the host body. Active modulation of the host immune response by tick saliva is thus required for the tick to complete its blood meal. Upon attachment, the tick inoculates its saliva containing a repertoire of bioactive molecules that help ticks to attach to the host, to overcome host hemostasis, and to prevent host pain and itching and the concomitant scratching. Furthermore, the tick must deal with the host innate immunity during primary infestation and with innate and adaptive immunity in subsequent infestations. The immunomodulatory properties of tick saliva and the roles of individual salivary components at the tick-host interface are described in this chapter, dealing with virtually all levels of nonspecific and specific host immune

Název v anglickém jazyce

Tick saliva-mediated immunomodulation of the vertebrate host

Popis výsledku anglicky

The feeding period of hard ticks often exceeds one week and makes tick infestation a considerable intervention to host physiology. A broad range of inflammatory and immune reactions take place locally at the feeding site as well as systemically within the host body. Active modulation of the host immune response by tick saliva is thus required for the tick to complete its blood meal. Upon attachment, the tick inoculates its saliva containing a repertoire of bioactive molecules that help ticks to attach to the host, to overcome host hemostasis, and to prevent host pain and itching and the concomitant scratching. Furthermore, the tick must deal with the host innate immunity during primary infestation and with innate and adaptive immunity in subsequent infestations. The immunomodulatory properties of tick saliva and the roles of individual salivary components at the tick-host interface are described in this chapter, dealing with virtually all levels of nonspecific and specific host immune

Druh

C - Kapitola v odborné knize

CEP obor

EC - Imunologie

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2012

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název knihy nebo sborníku

Ticks: Disease, Management and Control

ISBN

978-1-62081-136-8

Počet stran výsledku

17

Strana od-do

19-36

Počet stran knihy

254

Název nakladatele

Nova Science Publishers, Inc

Místo vydání

New York

Kód UT WoS kapitoly

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