Make It, Take It, or Leave It: Heme Metabolism of Parasites

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F13%3A00392770" target="_blank" >RIV/60077344:_____/13:00392770 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/60076658:12310/13:43885044

Výsledek na webu

<a href="http://dx.doi.org/10.1371/journal.ppat.1003088" target="_blank" >http://dx.doi.org/10.1371/journal.ppat.1003088</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1371/journal.ppat.1003088" target="_blank" >10.1371/journal.ppat.1003088</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Make It, Take It, or Leave It: Heme Metabolism of Parasites

Popis výsledku v původním jazyce

Heme and other tetrapyrroles, often called ?the colors of life, belong to the most important molecules of almost all extant organisms. They are synthesized by a common multistep pathway that is highly conserved throughout the tree of life [1]. One of thetetrapyrrole products is chlorophyll, the green pigment of plants and other phototrophs, which captures the energy of the sun. Vitamin B12, the most complex tetrapyrrole, is involved in DNA synthesis and energy metabolism [2]. The major product of tetrapyrrole biosynthesis in non-photosynthetic organisms is heme, an iron-coordinated porphyrin with the capacity to transfer electrons and bind diatomic gases. Here we summarize the current understanding of different aspects of heme metabolism in parasiticeukaryotes, including the synthesis and uptake of heme and its detoxification. A differential need for heme in distinct parasitic groups and the suitability of heme metabolism as a drug target for treating parasite-borne diseases are also

Název v anglickém jazyce

Make It, Take It, or Leave It: Heme Metabolism of Parasites

Popis výsledku anglicky

Heme and other tetrapyrroles, often called ?the colors of life, belong to the most important molecules of almost all extant organisms. They are synthesized by a common multistep pathway that is highly conserved throughout the tree of life [1]. One of thetetrapyrrole products is chlorophyll, the green pigment of plants and other phototrophs, which captures the energy of the sun. Vitamin B12, the most complex tetrapyrrole, is involved in DNA synthesis and energy metabolism [2]. The major product of tetrapyrrole biosynthesis in non-photosynthetic organisms is heme, an iron-coordinated porphyrin with the capacity to transfer electrons and bind diatomic gases. Here we summarize the current understanding of different aspects of heme metabolism in parasiticeukaryotes, including the synthesis and uptake of heme and its detoxification. A differential need for heme in distinct parasitic groups and the suitability of heme metabolism as a drug target for treating parasite-borne diseases are also

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EB - Genetika a molekulární biologie

OECD FORD obor

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Projekt

<a href="/cs/project/GAP305%2F11%2F2179" target="_blank" >GAP305/11/2179: Charakteristika železosirných složek u T. brucei</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Plos Pathogens

ISSN

1553-7374

e-ISSN

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Svazek periodika

9

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

6

Strana od-do

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Kód UT WoS článku

000314464600008

EID výsledku v databázi Scopus

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