The role of innate immune cells in obese adipose tissue inflammation and development of insulin resistance

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F13%3A00396406" target="_blank" >RIV/60077344:_____/13:00396406 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1160/TH12-09-0703" target="_blank" >http://dx.doi.org/10.1160/TH12-09-0703</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1160/TH12-09-0703" target="_blank" >10.1160/TH12-09-0703</a>

Jazyk výsledku

angličtina

Název v původním jazyce

The role of innate immune cells in obese adipose tissue inflammation and development of insulin resistance

Popis výsledku v původním jazyce

Obesity is characterised by a chronic state of low-grade inflammation in different tissues including the vasculature. There is a causal link between adipose tissue (AT) inflammation and obesity-related metabolic complications, such as the development ofinsulin resistance and subsequently of type 2 diabetes. Intense efforts in the recent years have aimed at dissecting the pathophysiology of AT inflammation. The role of both innate and adaptive immune cells, such as macrophages or cytotoxic T cells in ATinflammation has been demonstrated. Besides these cells, more leukocyte subpopulations have been recently implicated in obesity, including neutrophils and eosinophils, mast cells, natural killer cells or dendritic cells. The involvement of multiple leukocyte subpopulations underlines the complexity of obesity-associated AT inflammation. In this review, we discuss the role of innate immune cells in AT inflammation, obesity and related metabolic disorders.

Název v anglickém jazyce

The role of innate immune cells in obese adipose tissue inflammation and development of insulin resistance

Popis výsledku anglicky

Obesity is characterised by a chronic state of low-grade inflammation in different tissues including the vasculature. There is a causal link between adipose tissue (AT) inflammation and obesity-related metabolic complications, such as the development ofinsulin resistance and subsequently of type 2 diabetes. Intense efforts in the recent years have aimed at dissecting the pathophysiology of AT inflammation. The role of both innate and adaptive immune cells, such as macrophages or cytotoxic T cells in ATinflammation has been demonstrated. Besides these cells, more leukocyte subpopulations have been recently implicated in obesity, including neutrophils and eosinophils, mast cells, natural killer cells or dendritic cells. The involvement of multiple leukocyte subpopulations underlines the complexity of obesity-associated AT inflammation. In this review, we discuss the role of innate immune cells in AT inflammation, obesity and related metabolic disorders.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EC - Imunologie

OECD FORD obor

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Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Thrombosis and Haemostasis

ISSN

0340-6245

e-ISSN

—

Svazek periodika

109

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

8

Strana od-do

399-406

Kód UT WoS článku

000316164200007

EID výsledku v databázi Scopus

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