A Nod to disease vectors: mitigation of pathogen sensing by arthropod saliva

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F13%3A00421240" target="_blank" >RIV/60077344:_____/13:00421240 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.3389/fmicb.2013.00308" target="_blank" >http://dx.doi.org/10.3389/fmicb.2013.00308</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3389/fmicb.2013.00308" target="_blank" >10.3389/fmicb.2013.00308</a>

Jazyk výsledku

angličtina

Název v původním jazyce

A Nod to disease vectors: mitigation of pathogen sensing by arthropod saliva

Popis výsledku v původním jazyce

Arthropod saliva possesses anti-hemostatic, anesthetic, and anti-inflammatory properties that facilitate feeding and, inadvertently, dissemination of pathogens. Vector-borne diseases caused by these pathogens affect millions of people each year. Many studies address the impact of arthropod salivary proteins on various immunological components. However, whether and how arthropod saliva counters Nod-like (NLR) sensing remains elusive. NLRs are innate immune pattern recognition molecules involved in detecting microbial molecules and danger signals. Nod1/2 signaling results in activation of the nuclear factor-?B and the mitogen-activated protein kinase pathways. Caspase-1 NLRs regulate the inflammasome- a protein scaffold that governs the maturation of interleukin (IL)-1? and IL-18. Recently, several vector-borne pathogens have been shown to induce NLR activation in immune cells. Here, we provide a brief overview of NLR signaling and discuss clinically relevant vector-borne pathogens recog

Název v anglickém jazyce

A Nod to disease vectors: mitigation of pathogen sensing by arthropod saliva

Popis výsledku anglicky

Arthropod saliva possesses anti-hemostatic, anesthetic, and anti-inflammatory properties that facilitate feeding and, inadvertently, dissemination of pathogens. Vector-borne diseases caused by these pathogens affect millions of people each year. Many studies address the impact of arthropod salivary proteins on various immunological components. However, whether and how arthropod saliva counters Nod-like (NLR) sensing remains elusive. NLRs are innate immune pattern recognition molecules involved in detecting microbial molecules and danger signals. Nod1/2 signaling results in activation of the nuclear factor-?B and the mitogen-activated protein kinase pathways. Caspase-1 NLRs regulate the inflammasome- a protein scaffold that governs the maturation of interleukin (IL)-1? and IL-18. Recently, several vector-borne pathogens have been shown to induce NLR activation in immune cells. Here, we provide a brief overview of NLR signaling and discuss clinically relevant vector-borne pathogens recog

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EC - Imunologie

OECD FORD obor

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Projekt

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Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Frontiers in Microbiolgy

ISSN

1664-302X

e-ISSN

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Svazek periodika

4

Číslo periodika v rámci svazku

OCT 2013

Stát vydavatele periodika

CH - Švýcarská konfederace

Počet stran výsledku

14

Strana od-do

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Kód UT WoS článku

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EID výsledku v databázi Scopus

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