Generating different genetic expression patterns in the early embryo: insights from the mouse model

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F13%3A00425926" target="_blank" >RIV/60077344:_____/13:00425926 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/60076658:12310/13:43885531

Výsledek na webu

<a href="http://www.sciencedirect.com/science/article/pii/S1472648313002435" target="_blank" >http://www.sciencedirect.com/science/article/pii/S1472648313002435</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.rbmo.2013.03.024" target="_blank" >10.1016/j.rbmo.2013.03.024</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Generating different genetic expression patterns in the early embryo: insights from the mouse model

Popis výsledku v původním jazyce

The divergence of two differentiating extraembryonic cell types (trophectoderm and primitive endoderm) from the pluripotent epiblast population (the source of fetal progenitor cells) by the blastocyst stage of mouse development relies upon the activationand execution of lineage-specific gene expression programmes. While our understanding of the central transcription factor 'effectors' directing these cell-fate choices has accumulated rapidly, what is less clear is how the differential expression of such genes within the diverging lineages is initially generated. This review summarizes and consolidates current understanding. I introduce the traditional concept and importance of a cell's spatial location within the embryo, referencing recent mechanisticand molecular insights relating to cell fate. Additionally, I address the growing body of evidence that suggests that heterogeneities among blastomeres precede, and possibly inform, their spatial segregation in the embryo. I also discuss

Název v anglickém jazyce

Generating different genetic expression patterns in the early embryo: insights from the mouse model

Popis výsledku anglicky

The divergence of two differentiating extraembryonic cell types (trophectoderm and primitive endoderm) from the pluripotent epiblast population (the source of fetal progenitor cells) by the blastocyst stage of mouse development relies upon the activationand execution of lineage-specific gene expression programmes. While our understanding of the central transcription factor 'effectors' directing these cell-fate choices has accumulated rapidly, what is less clear is how the differential expression of such genes within the diverging lineages is initially generated. This review summarizes and consolidates current understanding. I introduce the traditional concept and importance of a cell's spatial location within the embryo, referencing recent mechanisticand molecular insights relating to cell fate. Additionally, I address the growing body of evidence that suggests that heterogeneities among blastomeres precede, and possibly inform, their spatial segregation in the embryo. I also discuss

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EB - Genetika a molekulární biologie

OECD FORD obor

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Projekt

<a href="/cs/project/GA13-03295S" target="_blank" >GA13-03295S: Funkční charakterizace nových kandidátních genů ovlivňujících buněčný osud u preimplantačního stádia vývoje myši</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Reproductive BioMedicine Online

ISSN

1472-6483

e-ISSN

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Svazek periodika

27

Číslo periodika v rámci svazku

6

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

7

Strana od-do

586-592

Kód UT WoS článku

000328079400003

EID výsledku v databázi Scopus

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