Identification and partial characterisation of new members of the Ixodes ricinus defensin family

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F14%3A00430609" target="_blank" >RIV/60077344:_____/14:00430609 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/60076658:12310/14:43887333

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.gene.2014.03.002" target="_blank" >http://dx.doi.org/10.1016/j.gene.2014.03.002</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.gene.2014.03.002" target="_blank" >10.1016/j.gene.2014.03.002</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Identification and partial characterisation of new members of the Ixodes ricinus defensin family

Popis výsledku v původním jazyce

The hard-bodied tick Ixodes ricinus (castor bean tick) is the most common tick species in Europe.I. ricinus is a vector of the causative agents of diseases that affect humans and animals including tick-borne encephalitis, borreliosis, tick-borne fever and babesiosis. The innate immune system provides ticks with quite an efficient defence against some pathogenic microorganisms in the event of their penetration into the tick body or through the blood meal. Antimicrobial peptides (AMPs) constitute an important feature of the tick immune system. Defensins are a well-known class of AMPs. Members of the defensin family of proteins have been reported in several tick species. So far, only two defensins had been identified from I. ricinus. In this study, we report the identification of six novel putative defensins from I. ricinus at the genomic and transcriptional levels. At the genomic level they show differences with one being intronless, while others contain two introns. The expression patte

Název v anglickém jazyce

Identification and partial characterisation of new members of the Ixodes ricinus defensin family

Popis výsledku anglicky

The hard-bodied tick Ixodes ricinus (castor bean tick) is the most common tick species in Europe.I. ricinus is a vector of the causative agents of diseases that affect humans and animals including tick-borne encephalitis, borreliosis, tick-borne fever and babesiosis. The innate immune system provides ticks with quite an efficient defence against some pathogenic microorganisms in the event of their penetration into the tick body or through the blood meal. Antimicrobial peptides (AMPs) constitute an important feature of the tick immune system. Defensins are a well-known class of AMPs. Members of the defensin family of proteins have been reported in several tick species. So far, only two defensins had been identified from I. ricinus. In this study, we report the identification of six novel putative defensins from I. ricinus at the genomic and transcriptional levels. At the genomic level they show differences with one being intronless, while others contain two introns. The expression patte

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EB - Genetika a molekulární biologie

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Gene

ISSN

0378-1119

e-ISSN

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Svazek periodika

540

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

7

Strana od-do

146-152

Kód UT WoS článku

000335102200003

EID výsledku v databázi Scopus

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