Infection and injury of human astrocytes by tick-borne encephalitis virus

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F14%3A00435256" target="_blank" >RIV/60077344:_____/14:00435256 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/60076658:12310/14:43887264 RIV/00027162:_____/14:#0001180 RIV/00027162:_____/14:#0001333

Výsledek na webu

<a href="http://dx.doi.org/10.1099/vir.0.068411-0" target="_blank" >http://dx.doi.org/10.1099/vir.0.068411-0</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1099/vir.0.068411-0" target="_blank" >10.1099/vir.0.068411-0</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Infection and injury of human astrocytes by tick-borne encephalitis virus

Popis výsledku v původním jazyce

Tick-borne encephalitis (TBE), a disease caused by tick-borne encephalitis virus (TBEV), represents the most important flaviviral neural infection in Europe and north-eastern Asia. In the central nervous system (CNS), neurons are the primary target for TBEV infection; however, infection of non-neuronal CNS cells, such as astrocytes, is not well understood. In this study, we investigated the interaction between TBEV and primary human astrocytes. We report for the first time, to the best of our knowledge,that primary human astrocytes are sensitive to TBEV infection, although the infection did not affect their viability. The infection induced a marked increase in the expression of glial fibrillary acidic protein, a marker of astrocyte activation. In addition, expression of matrix metalloproteinase 9 and several key pro-inflammatory cytokines/chemokines (e.g. tumour necrosis factor alpha, interferon alpha, interleukin (IL)-1beta, IL-6, IL-8, interferon gamma-induced protein 10, macrophage

Název v anglickém jazyce

Infection and injury of human astrocytes by tick-borne encephalitis virus

Popis výsledku anglicky

Tick-borne encephalitis (TBE), a disease caused by tick-borne encephalitis virus (TBEV), represents the most important flaviviral neural infection in Europe and north-eastern Asia. In the central nervous system (CNS), neurons are the primary target for TBEV infection; however, infection of non-neuronal CNS cells, such as astrocytes, is not well understood. In this study, we investigated the interaction between TBEV and primary human astrocytes. We report for the first time, to the best of our knowledge,that primary human astrocytes are sensitive to TBEV infection, although the infection did not affect their viability. The infection induced a marked increase in the expression of glial fibrillary acidic protein, a marker of astrocyte activation. In addition, expression of matrix metalloproteinase 9 and several key pro-inflammatory cytokines/chemokines (e.g. tumour necrosis factor alpha, interferon alpha, interleukin (IL)-1beta, IL-6, IL-8, interferon gamma-induced protein 10, macrophage

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EE - Mikrobiologie, virologie

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of General Virology

ISSN

0022-1317

e-ISSN

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Svazek periodika

95

Číslo periodika v rámci svazku

Pt 11

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

16

Strana od-do

2411-2426

Kód UT WoS článku

000345309600009

EID výsledku v databázi Scopus

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