Knockdown of adipokinetic hormone synthesis increases susceptibility to oxidative stress in Drosophila ? A role for dFoxO?

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F15%3A00444024" target="_blank" >RIV/60077344:_____/15:00444024 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/60076658:12310/15:43888761

Výsledek na webu

<a href="http://www.sciencedirect.com/science/article/pii/S1532045615000265" target="_blank" >http://www.sciencedirect.com/science/article/pii/S1532045615000265</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.cbpc.2015.03.006" target="_blank" >10.1016/j.cbpc.2015.03.006</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Knockdown of adipokinetic hormone synthesis increases susceptibility to oxidative stress in Drosophila ? A role for dFoxO?

Popis výsledku v původním jazyce

Signaling pathways of insect adipokinetic hormones (AKHs) in anti-oxidative response are unclear. Exposure to hydrogen peroxide (HP) revealed that AKH-RNAi flies showed significantly higher mortality than AKH-oex or control lines. AKH-RNAi flies had significantly less dFoxO transcript and translated protein compared to control and AKH-oex flies in un-challenged condition as well as when challenged with HP. Sestrin ? a major antioxidant defense protein and one of the targets of dFoxO ? was also significantly down-regulated in AKH-RNAi flies (both unchallenged and challenged with HP) compared to control flies and flies with over-expressed AKH. These findings imply that dFoxO may act downstream of AKH as a transcription factor to mediate response to OS inD. melanogaster.

Název v anglickém jazyce

Knockdown of adipokinetic hormone synthesis increases susceptibility to oxidative stress in Drosophila ? A role for dFoxO?

Popis výsledku anglicky

Signaling pathways of insect adipokinetic hormones (AKHs) in anti-oxidative response are unclear. Exposure to hydrogen peroxide (HP) revealed that AKH-RNAi flies showed significantly higher mortality than AKH-oex or control lines. AKH-RNAi flies had significantly less dFoxO transcript and translated protein compared to control and AKH-oex flies in un-challenged condition as well as when challenged with HP. Sestrin ? a major antioxidant defense protein and one of the targets of dFoxO ? was also significantly down-regulated in AKH-RNAi flies (both unchallenged and challenged with HP) compared to control flies and flies with over-expressed AKH. These findings imply that dFoxO may act downstream of AKH as a transcription factor to mediate response to OS inD. melanogaster.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

ED - Fyziologie

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Comparative Biochemistry and Physiology Part C

ISSN

1532-0456

e-ISSN

—

Svazek periodika

171

Číslo periodika v rámci svazku

May 01

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

7

Strana od-do

8-14

Kód UT WoS článku

000354343400002

EID výsledku v databázi Scopus

2-s2.0-84925783892