The first two cell-fate decisions of preimplantation mouse embryo development are not functionally independent
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F15%3A00451070" target="_blank" >RIV/60077344:_____/15:00451070 - isvavai.cz</a>
Nalezeny alternativní kódy
RIV/60076658:12310/15:43889025
Výsledek na webu
<a href="http://www.nature.com/articles/srep15034" target="_blank" >http://www.nature.com/articles/srep15034</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1038/srep15034" target="_blank" >10.1038/srep15034</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
The first two cell-fate decisions of preimplantation mouse embryo development are not functionally independent
Popis výsledku v původním jazyce
During mouse preimplantation embryo development, three distinct cell lineages are formed, represented by the differentiating trophectoderm (TE), primitive endoderm (PrE) and the pluripotent epiblast (EPI). Classically, lineage derivation has been presented as a two-step process whereby outer TE cells are first segregated from inner-cell mass (ICM), followed by ICM refinement into either the PrE or EPI. As ICM founders can be produced following the fourth or fifth cleavage divisions, their potential to equally contribute to EPI and PrE is contested. Thus, modelling the early sequestration of ICM founders from TE-differentiation after the fourth cleavage division, we examined ICM lineage contribution of varying sized cell clones unable to initiate TE-differentiation. Such TE-inhibited ICM cells do not equally contribute to EPI and PrE and are significantly biased to form EPI. This bias is not caused by enhanced expression of the EPI marker Nanog, nor correlated with reduced apical polari
Název v anglickém jazyce
The first two cell-fate decisions of preimplantation mouse embryo development are not functionally independent
Popis výsledku anglicky
During mouse preimplantation embryo development, three distinct cell lineages are formed, represented by the differentiating trophectoderm (TE), primitive endoderm (PrE) and the pluripotent epiblast (EPI). Classically, lineage derivation has been presented as a two-step process whereby outer TE cells are first segregated from inner-cell mass (ICM), followed by ICM refinement into either the PrE or EPI. As ICM founders can be produced following the fourth or fifth cleavage divisions, their potential to equally contribute to EPI and PrE is contested. Thus, modelling the early sequestration of ICM founders from TE-differentiation after the fourth cleavage division, we examined ICM lineage contribution of varying sized cell clones unable to initiate TE-differentiation. Such TE-inhibited ICM cells do not equally contribute to EPI and PrE and are significantly biased to form EPI. This bias is not caused by enhanced expression of the EPI marker Nanog, nor correlated with reduced apical polari
Klasifikace
Druh
J<sub>x</sub> - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
CEP obor
EB - Genetika a molekulární biologie
OECD FORD obor
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Návaznosti výsledku
Projekt
<a href="/cs/project/GA13-03295S" target="_blank" >GA13-03295S: Funkční charakterizace nových kandidátních genů ovlivňujících buněčný osud u preimplantačního stádia vývoje myši</a><br>
Návaznosti
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Ostatní
Rok uplatnění
2015
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Scientific Reports
ISSN
2045-2322
e-ISSN
—
Svazek periodika
5
Číslo periodika v rámci svazku
article no. 15034
Stát vydavatele periodika
GB - Spojené království Velké Británie a Severního Irska
Počet stran výsledku
16
Strana od-do
—
Kód UT WoS článku
000362642100002
EID výsledku v databázi Scopus
2-s2.0-84944187093