Tribolium castaneum defensins are primarily active against Gram-positive bacteria

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F15%3A00451350" target="_blank" >RIV/60077344:_____/15:00451350 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.jip.2015.10.009" target="_blank" >http://dx.doi.org/10.1016/j.jip.2015.10.009</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.jip.2015.10.009" target="_blank" >10.1016/j.jip.2015.10.009</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Tribolium castaneum defensins are primarily active against Gram-positive bacteria

Popis výsledku v původním jazyce

The red flour beetle Tribolium castaneum is a destructive insect pest of stored food and feed products, and a model organism for development, evolutionary biology and immunity. The insect innate immune system includes antimicrobial peptides (AMPs) with awide spectrum of targets including viruses, bacteria, fungi and parasites. Defensins are an evolutionarily-conserved class of AMPs and a potential new source of antimicrobial agents. In this context, we report the antimicrobial activity, phylogenetic and structural properties of three T. castaneum defensins (Def1, Def2 and Def3) and their relevance in the immunity of T. castaneum against bacterial pathogens. All three recombinant defensins showed bactericidal activity against Micrococcus luteus and Bacillus thuringiensis serovar tolworthi, but only Def1 and Def2 showed a bacteriostatic effect against Staphylococcus epidermidis. None of the defensins showed activity against the Gram-negative bacteria Escherichia coli and Pseudomonas ent

Název v anglickém jazyce

Tribolium castaneum defensins are primarily active against Gram-positive bacteria

Popis výsledku anglicky

The red flour beetle Tribolium castaneum is a destructive insect pest of stored food and feed products, and a model organism for development, evolutionary biology and immunity. The insect innate immune system includes antimicrobial peptides (AMPs) with awide spectrum of targets including viruses, bacteria, fungi and parasites. Defensins are an evolutionarily-conserved class of AMPs and a potential new source of antimicrobial agents. In this context, we report the antimicrobial activity, phylogenetic and structural properties of three T. castaneum defensins (Def1, Def2 and Def3) and their relevance in the immunity of T. castaneum against bacterial pathogens. All three recombinant defensins showed bactericidal activity against Micrococcus luteus and Bacillus thuringiensis serovar tolworthi, but only Def1 and Def2 showed a bacteriostatic effect against Staphylococcus epidermidis. None of the defensins showed activity against the Gram-negative bacteria Escherichia coli and Pseudomonas ent

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EI - Biotechnologie a bionika

OECD FORD obor

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Projekt

<a href="/cs/project/EE2.3.30.0032" target="_blank" >EE2.3.30.0032: Vytvoření postdoktorandských pozic na Biologickém centru AV ČR k rozvoji biologických disciplín a dosažení globální konkurenceschopnosti</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Invertebrate Pathology

ISSN

0022-2011

e-ISSN

—

Svazek periodika

132

Číslo periodika v rámci svazku

NOV 2015

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

8

Strana od-do

208-215

Kód UT WoS článku

000365630200023

EID výsledku v databázi Scopus

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