Role of adipokinetic hormone and adenosine in the anti-stress response in Drosophila melanogaster

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F16%3A00461372" target="_blank" >RIV/60077344:_____/16:00461372 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/60076658:12310/16:43890868

Výsledek na webu

<a href="http://www.sciencedirect.com/science/article/pii/S0022191016301937" target="_blank" >http://www.sciencedirect.com/science/article/pii/S0022191016301937</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.jinsphys.2016.06.010" target="_blank" >10.1016/j.jinsphys.2016.06.010</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Role of adipokinetic hormone and adenosine in the anti-stress response in Drosophila melanogaster

Popis výsledku v původním jazyce

The role of adipokinetic hormone (AKH) and adenosine in the anti-stress response was studied in Drosophila melanogaster larvae and adults carrying a mutation in the Akh gene (Akh1), the adenosine receptor gene (AdoR1), or in both of these genes (Akh1 AdoR1 double mutant). Stress was induced by starvation or by the addition of an oxidative stressor paraquat (PQ) to food. All oxidative stress characteristics modified by mutations in Akh gene were restored or even improved by rescue’ mutation in flies which ectopically express Akh. Thus, the results of the present study demonstrate the important roles of AKH and adenosine in the anti-stress response elicited by PQ in a D. melanogaster model, and provide the first evidence for the involvement of adenosine in the anti-oxidative stress response in insects.

Název v anglickém jazyce

Role of adipokinetic hormone and adenosine in the anti-stress response in Drosophila melanogaster

Popis výsledku anglicky

The role of adipokinetic hormone (AKH) and adenosine in the anti-stress response was studied in Drosophila melanogaster larvae and adults carrying a mutation in the Akh gene (Akh1), the adenosine receptor gene (AdoR1), or in both of these genes (Akh1 AdoR1 double mutant). Stress was induced by starvation or by the addition of an oxidative stressor paraquat (PQ) to food. All oxidative stress characteristics modified by mutations in Akh gene were restored or even improved by rescue’ mutation in flies which ectopically express Akh. Thus, the results of the present study demonstrate the important roles of AKH and adenosine in the anti-stress response elicited by PQ in a D. melanogaster model, and provide the first evidence for the involvement of adenosine in the anti-oxidative stress response in insects.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

ED - Fyziologie

OECD FORD obor

—

Projekt

<a href="/cs/project/GA14-07172S" target="_blank" >GA14-07172S: Anti-stresové reakce regulující metabolickou homeostázu u hmyzu</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2016

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Insect Physiology

ISSN

0022-1910

e-ISSN

—

Svazek periodika

91-92

Číslo periodika v rámci svazku

AUG 01

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

9

Strana od-do

39-47

Kód UT WoS článku

000381532000006

EID výsledku v databázi Scopus

2-s2.0-84977512429