Prevalence and molecular characteristics of urinary and intestinal microsporidia infections in renal transplant recipients

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F16%3A00461952" target="_blank" >RIV/60077344:_____/16:00461952 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/60076658:12220/16:43891190

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.cmi.2016.01.014" target="_blank" >http://dx.doi.org/10.1016/j.cmi.2016.01.014</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.cmi.2016.01.014" target="_blank" >10.1016/j.cmi.2016.01.014</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Prevalence and molecular characteristics of urinary and intestinal microsporidia infections in renal transplant recipients

Popis výsledku v původním jazyce

Transplant recipients have been identified as a new risk group for microsporidia infection. We characterize for the first time the prevalence of microsporidia in intestinal and urinary tracts of renal transplant recipients. Molecular examination of 86 patients showed that 25.5% of them were infected; 86% were confirmed to have pathogens in their urine and 45.5% in stool. Among positive patients, 32% had microsporidia confirmed in both urine and stool. Genotyping revealed Encephalitozoon cuniculi (59%) and Enterocytozoon bieneusi (23%) monoinfections as well as coinfections with both species (18%). Moreover, we found diarrhoea and fever as symptoms significantly associated with microsporidia presence. Our results indicate that microsporidial infection should be considered in the assessment of renal transplant recipients, especially in the urinary tract, even if asymptomatic. Molecular identification of microsporidia species is relevant because of their different susceptibility for treatment. (C) 2016 European Society of Clinical Microbiology and Infectious Diseases.

Název v anglickém jazyce

Prevalence and molecular characteristics of urinary and intestinal microsporidia infections in renal transplant recipients

Popis výsledku anglicky

Transplant recipients have been identified as a new risk group for microsporidia infection. We characterize for the first time the prevalence of microsporidia in intestinal and urinary tracts of renal transplant recipients. Molecular examination of 86 patients showed that 25.5% of them were infected; 86% were confirmed to have pathogens in their urine and 45.5% in stool. Among positive patients, 32% had microsporidia confirmed in both urine and stool. Genotyping revealed Encephalitozoon cuniculi (59%) and Enterocytozoon bieneusi (23%) monoinfections as well as coinfections with both species (18%). Moreover, we found diarrhoea and fever as symptoms significantly associated with microsporidia presence. Our results indicate that microsporidial infection should be considered in the assessment of renal transplant recipients, especially in the urinary tract, even if asymptomatic. Molecular identification of microsporidia species is relevant because of their different susceptibility for treatment. (C) 2016 European Society of Clinical Microbiology and Infectious Diseases.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

EB - Genetika a molekulární biologie

OECD FORD obor

—

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2016

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Clinical Microbiology and Infection

ISSN

1198-743X

e-ISSN

—

Svazek periodika

22

Číslo periodika v rámci svazku

5

Stát vydavatele periodika

CA - Kanada

Počet stran výsledku

5

Strana od-do

—

Kód UT WoS článku

000376654700026

EID výsledku v databázi Scopus

2-s2.0-84960332898