Heat Shock Proteins in Vector-pathogen Interactions: The Anaplasma phagocytophilum Model

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F17%3A00502020" target="_blank" >RIV/60077344:_____/17:00502020 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1007/978-3-319-73377-7_15" target="_blank" >http://dx.doi.org/10.1007/978-3-319-73377-7_15</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/978-3-319-73377-7_15" target="_blank" >10.1007/978-3-319-73377-7_15</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Heat Shock Proteins in Vector-pathogen Interactions: The Anaplasma phagocytophilum Model

Popis výsledku v původním jazyce

Anaplasma phogocytophihun is an emerging zoonotic pathogen that is transmitted by Ixodes ticks and causes human granulocytic anaplasmosis. Several recent studies have shown that tick infection by A. phagocytophilum induces complex changes mediated by different, mechanisms such as remodeling of cytoskeleton, inhibition of cell apoptosis, modification of metabolism and cell epigenetics, manipulation of the immune response and stress response. In particular, heat shock proteins (lisp), a group of highly conserved proteins, play an important role in tick pathogen interactions. Not only tick ftsp mediate the response to A. phagocytophibun infection, but also bacterial lisp bind tick and vertebrate host cells. Herein, we reviewed the literature and provided new insides on the role of bacterial and tick lisp in tick-pathogen interactions. We combined the analysis of published data on genomics, transcriptomics and proteomics of the response of Ixodes scapularis ticks to A. phagocytophilum infection. In addition, functional. studies were conducted to test some of the hypotheses on the role of tick Hsp in response to A. phagocytophilum infection. These results provide a more comprehensive view of the major Hsp involved in the response to pathogen infection in ticks.

Název v anglickém jazyce

Heat Shock Proteins in Vector-pathogen Interactions: The Anaplasma phagocytophilum Model

Popis výsledku anglicky

Anaplasma phogocytophihun is an emerging zoonotic pathogen that is transmitted by Ixodes ticks and causes human granulocytic anaplasmosis. Several recent studies have shown that tick infection by A. phagocytophilum induces complex changes mediated by different, mechanisms such as remodeling of cytoskeleton, inhibition of cell apoptosis, modification of metabolism and cell epigenetics, manipulation of the immune response and stress response. In particular, heat shock proteins (lisp), a group of highly conserved proteins, play an important role in tick pathogen interactions. Not only tick ftsp mediate the response to A. phagocytophibun infection, but also bacterial lisp bind tick and vertebrate host cells. Herein, we reviewed the literature and provided new insides on the role of bacterial and tick lisp in tick-pathogen interactions. We combined the analysis of published data on genomics, transcriptomics and proteomics of the response of Ixodes scapularis ticks to A. phagocytophilum infection. In addition, functional. studies were conducted to test some of the hypotheses on the role of tick Hsp in response to A. phagocytophilum infection. These results provide a more comprehensive view of the major Hsp involved in the response to pathogen infection in ticks.

Druh

C - Kapitola v odborné knize

CEP obor

—

OECD FORD obor

10603 - Genetics and heredity (medical genetics to be 3)

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název knihy nebo sborníku

Heat Shock Proteins in Veterinary Medicine and Sciences

ISBN

978-3-319-73376-0

Počet stran výsledku

24

Strana od-do

"Roč. 12 /2017/"

Počet stran knihy

398

Název nakladatele

Springer International Publishing

Místo vydání

Cham

Kód UT WoS kapitoly

000448887200016