Molecular Targets to Impair Blood Meal Processing in Ticks

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F18%3A00503008" target="_blank" >RIV/60077344:_____/18:00503008 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1002/9783527802883.ch7" target="_blank" >http://dx.doi.org/10.1002/9783527802883.ch7</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/9783527802883.ch7" target="_blank" >10.1002/9783527802883.ch7</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Molecular Targets to Impair Blood Meal Processing in Ticks

Popis výsledku v původním jazyce

Feeding and digestion of host blood are key physiological processes providing essential nutrients for the development and fecundity of ticks. Ingested host blood, which exceeds the weight of unfed females by more than one hundred times, is concentrated and stored in the tick gut lumen, gradually being taken up by digestive cells, and intracellularly digested by a multi‐enzyme network of acidic aspartic and cysteine endo‐ and exo‐peptidases. Digestion of hemoglobin, the major protein component of blood, results in the release of a vast excess of potentially toxic heme. In most eukaryotic cells, heme and iron homeostasis is based on a balanced flux between heme biosynthesis and heme degradation, mediated by heme oxygenase. In contrast, ticks are not capable of synthesizing or degrading heme. Therefore, ticks have evolved specific molecular mechanisms of heme and iron acquisition, detoxification, intracellular trafficking, and inter‐tissue transport. This chapter reviews current knowledge on the molecular mechanisms of these processes and discusses their potential as targets for antitick interventions.

Název v anglickém jazyce

Molecular Targets to Impair Blood Meal Processing in Ticks

Popis výsledku anglicky

Feeding and digestion of host blood are key physiological processes providing essential nutrients for the development and fecundity of ticks. Ingested host blood, which exceeds the weight of unfed females by more than one hundred times, is concentrated and stored in the tick gut lumen, gradually being taken up by digestive cells, and intracellularly digested by a multi‐enzyme network of acidic aspartic and cysteine endo‐ and exo‐peptidases. Digestion of hemoglobin, the major protein component of blood, results in the release of a vast excess of potentially toxic heme. In most eukaryotic cells, heme and iron homeostasis is based on a balanced flux between heme biosynthesis and heme degradation, mediated by heme oxygenase. In contrast, ticks are not capable of synthesizing or degrading heme. Therefore, ticks have evolved specific molecular mechanisms of heme and iron acquisition, detoxification, intracellular trafficking, and inter‐tissue transport. This chapter reviews current knowledge on the molecular mechanisms of these processes and discusses their potential as targets for antitick interventions.

Druh

C - Kapitola v odborné knize

CEP obor

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OECD FORD obor

10606 - Microbiology

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název knihy nebo sborníku

Ectoparasites: Drug Discovery Against Moving Targets

ISBN

9783527341689

Počet stran výsledku

26

Strana od-do

139-165

Počet stran knihy

360

Název nakladatele

Wiley‐VCH Verlag GmbH & Co. KGaA.

Místo vydání

Wenheim

Kód UT WoS kapitoly

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