Mannitol treatment is not effective in therapy of rabies virus infection in mice
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F19%3A00519413" target="_blank" >RIV/60077344:_____/19:00519413 - isvavai.cz</a>
Nalezeny alternativní kódy
RIV/00027162:_____/19:N0000082
Výsledek na webu
<a href="https://www.sciencedirect.com/science/article/pii/S0264410X17317814?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0264410X17317814?via%3Dihub</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.vaccine.2017.12.028" target="_blank" >10.1016/j.vaccine.2017.12.028</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Mannitol treatment is not effective in therapy of rabies virus infection in mice
Popis výsledku v původním jazyce
Rabies is a deadly viral disease with an extremely high fatality rate in humans. Previously, it was suggested that an enhancement of the blood-brain barrier (BBB) permeability, which allows immune cells and/or antibodies to enter the central nervous system (CNS) tissue, is critical to clear the infection. In this study, we utilised mannitol to increase BBB permeability in mice infected with highly pathogenic silver-haired bat rabies virus (SHBRV). We found that intraperitoneal injection of mannitol causes a slight, transient increase of BBB permeability in the treated mice. SHBRV-infected mice were treated with intraperitoneally administered mannitol daily from day 3 or day 4 post-infection, but no effect of this treatment on the time of disease onset, clinical signs or survival was observed. This data indicates that the increase of BBB permeability by mannitol is not efficient in promoting CNS virus clearance in SHBRV-infected mice. (C) 2017 Elsevier Ltd. All rights reserved.
Název v anglickém jazyce
Mannitol treatment is not effective in therapy of rabies virus infection in mice
Popis výsledku anglicky
Rabies is a deadly viral disease with an extremely high fatality rate in humans. Previously, it was suggested that an enhancement of the blood-brain barrier (BBB) permeability, which allows immune cells and/or antibodies to enter the central nervous system (CNS) tissue, is critical to clear the infection. In this study, we utilised mannitol to increase BBB permeability in mice infected with highly pathogenic silver-haired bat rabies virus (SHBRV). We found that intraperitoneal injection of mannitol causes a slight, transient increase of BBB permeability in the treated mice. SHBRV-infected mice were treated with intraperitoneally administered mannitol daily from day 3 or day 4 post-infection, but no effect of this treatment on the time of disease onset, clinical signs or survival was observed. This data indicates that the increase of BBB permeability by mannitol is not efficient in promoting CNS virus clearance in SHBRV-infected mice. (C) 2017 Elsevier Ltd. All rights reserved.
Klasifikace
Druh
J<sub>imp</sub> - Článek v periodiku v databázi Web of Science
CEP obor
—
OECD FORD obor
30102 - Immunology
Návaznosti výsledku
Projekt
—
Návaznosti
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Ostatní
Rok uplatnění
2019
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Vaccine
ISSN
0264-410X
e-ISSN
—
Svazek periodika
37
Číslo periodika v rámci svazku
33
Stát vydavatele periodika
GB - Spojené království Velké Británie a Severního Irska
Počet stran výsledku
5
Strana od-do
4710-4714
Kód UT WoS článku
000480669000009
EID výsledku v databázi Scopus
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