The surfactant polyethoxylated tallowamine (POEA) reduces lifespan and inhibits fecundity in Drosophila melanogaster- In vivo and in vitro study

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F20%3A00510737" target="_blank" >RIV/60077344:_____/20:00510737 - isvavai.cz</a>

Výsledek na webu

<a href="https://www.sciencedirect.com/science/article/pii/S014765131931214X?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S014765131931214X?via%3Dihub</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.ecoenv.2019.109883" target="_blank" >10.1016/j.ecoenv.2019.109883</a>

Jazyk výsledku

angličtina

Název v původním jazyce

The surfactant polyethoxylated tallowamine (POEA) reduces lifespan and inhibits fecundity in Drosophila melanogaster- In vivo and in vitro study

Popis výsledku v původním jazyce

The effects of pure glyphosate [N-(phosphonomethyl)-glycine], RCP and a non-ionic surfactant – polyethoxylated tallowamine (POEA) were studied in the fruit fly Drosophila melanogaster in order to develop an understanding of the role of adjuvants in a popular glyphosate-based herbicide – Roundup® Concentrate Plus (RCP). Acute exposure to sub-lethal concentrations of RCP and POEA reduced lifespan of female flies compared to untreated controls or glyphosate. Negative geotaxis responses in female flies were reduced following acute exposure to sub-lethal concentrations of RCP and POEA whereas glyphosate did not significantly affect this response compared to untreated flies. Acute exposure to sub-lethal concentrations of RCP and POEA elevated protein carbonyl levels while markedly inhibiting carbonyl reductase activity whereas glyphosate treatment did not significantly affect protein carbonyl levels or carbonyl reductase activity. Fecundity was reduced following exposure to sub-lethal concentrations of RCP and POEA whereas glyphosate did not affect fecundity. In vitro treatment of ovarian stem sheath cells with sub-lethal concentrations of RCP and POEA revealed decreased cell viability and enhanced caspase activity indicative of pro-apoptotic processes compared to untreated controls. Glyphosate however was non-toxic at the concentration used. The results suggest that RCP and the surfactant POEA are more toxic than pure glyphosate and inhibit fecundity in Drosophila by inhibiting cell viability through enhanced apoptosis.

Název v anglickém jazyce

The surfactant polyethoxylated tallowamine (POEA) reduces lifespan and inhibits fecundity in Drosophila melanogaster- In vivo and in vitro study

Popis výsledku anglicky

The effects of pure glyphosate [N-(phosphonomethyl)-glycine], RCP and a non-ionic surfactant – polyethoxylated tallowamine (POEA) were studied in the fruit fly Drosophila melanogaster in order to develop an understanding of the role of adjuvants in a popular glyphosate-based herbicide – Roundup® Concentrate Plus (RCP). Acute exposure to sub-lethal concentrations of RCP and POEA reduced lifespan of female flies compared to untreated controls or glyphosate. Negative geotaxis responses in female flies were reduced following acute exposure to sub-lethal concentrations of RCP and POEA whereas glyphosate did not significantly affect this response compared to untreated flies. Acute exposure to sub-lethal concentrations of RCP and POEA elevated protein carbonyl levels while markedly inhibiting carbonyl reductase activity whereas glyphosate treatment did not significantly affect protein carbonyl levels or carbonyl reductase activity. Fecundity was reduced following exposure to sub-lethal concentrations of RCP and POEA whereas glyphosate did not affect fecundity. In vitro treatment of ovarian stem sheath cells with sub-lethal concentrations of RCP and POEA revealed decreased cell viability and enhanced caspase activity indicative of pro-apoptotic processes compared to untreated controls. Glyphosate however was non-toxic at the concentration used. The results suggest that RCP and the surfactant POEA are more toxic than pure glyphosate and inhibit fecundity in Drosophila by inhibiting cell viability through enhanced apoptosis.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

40106 - Agronomy, plant breeding and plant protection; (Agricultural biotechnology to be 4.4)

Projekt

<a href="/cs/project/EF18_070%2F0008772" target="_blank" >EF18_070/0008772: Rozšířený pohled na energetickou rovnováhu organismu: neurální integrace mezi signalizací inzulinu a adipokinetického hormonu.</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2020

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Ecotoxicology and Enviromental Safety

ISSN

0147-6513

e-ISSN

—

Svazek periodika

188

Číslo periodika v rámci svazku

JAN 30

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

8

Strana od-do

109883

Kód UT WoS článku

000503913900005

EID výsledku v databázi Scopus

2-s2.0-85074361084