Genomic basis of parallel adaptation varies with divergence in Arabidopsis and its relatives

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F21%3A00547550" target="_blank" >RIV/60077344:_____/21:00547550 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/67985939:_____/21:00547550 RIV/00216208:11310/21:10435810 RIV/60076658:12310/21:43905669

Výsledek na webu

<a href="https://doi.org/10.1073/pnas.2022713118" target="_blank" >https://doi.org/10.1073/pnas.2022713118</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1073/pnas.2022713118" target="_blank" >10.1073/pnas.2022713118</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Genomic basis of parallel adaptation varies with divergence in Arabidopsis and its relatives

Popis výsledku v původním jazyce

Parallel adaptation provides valuable insight into the predictability of evolutionary change through replicated natural experiments. A steadily increasing number of studies have demonstrated genomic parallelism, yet the magnitude of this parallelism varies depending on whether populations, species, or genera are compared. This led us to hypothesize that the magnitude of genomic parallelism scales with genetic divergence between lineages, but whether this is the case and the underlying evolutionary processes remain unknown. Here, we resequenced seven parallel lineages of two Arabidopsis species, which repeatedly adapted to challenging alpine environ- ments. By combining genome-wide divergence scans with model- based approaches, we detected a suite of 151 genes that show par- allel signatures of positive selection associated with alpine coloni- zation, involved in response to cold, high radiation, short season, herbivores, and pathogens. We complemented these parallel candi- dates with published gene lists from five additional alpine Brassica- ceae and tested our hypothesis on a broad scale spanning ∼0.02 to 18 My of divergence. Indeed, we found quantitatively variable ge- nomic parallelism whose extent significantly decreased with in- creasing divergence between the compared lineages. We further modeled parallel evolution over the Arabidopsis candidate genes and showed that a decreasing probability of repeated selection on the same standing or introgressed alleles drives the observed pat- tern of divergence-dependent parallelism. We therefore conclude that genetic divergence between populations, species, and genera, affecting the pool of shared variants, is an important factor in the predictability of genome evolution.

Název v anglickém jazyce

Genomic basis of parallel adaptation varies with divergence in Arabidopsis and its relatives

Popis výsledku anglicky

Parallel adaptation provides valuable insight into the predictability of evolutionary change through replicated natural experiments. A steadily increasing number of studies have demonstrated genomic parallelism, yet the magnitude of this parallelism varies depending on whether populations, species, or genera are compared. This led us to hypothesize that the magnitude of genomic parallelism scales with genetic divergence between lineages, but whether this is the case and the underlying evolutionary processes remain unknown. Here, we resequenced seven parallel lineages of two Arabidopsis species, which repeatedly adapted to challenging alpine environ- ments. By combining genome-wide divergence scans with model- based approaches, we detected a suite of 151 genes that show par- allel signatures of positive selection associated with alpine coloni- zation, involved in response to cold, high radiation, short season, herbivores, and pathogens. We complemented these parallel candi- dates with published gene lists from five additional alpine Brassica- ceae and tested our hypothesis on a broad scale spanning ∼0.02 to 18 My of divergence. Indeed, we found quantitatively variable ge- nomic parallelism whose extent significantly decreased with in- creasing divergence between the compared lineages. We further modeled parallel evolution over the Arabidopsis candidate genes and showed that a decreasing probability of repeated selection on the same standing or introgressed alleles drives the observed pat- tern of divergence-dependent parallelism. We therefore conclude that genetic divergence between populations, species, and genera, affecting the pool of shared variants, is an important factor in the predictability of genome evolution.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10611 - Plant sciences, botany

Projekt

<a href="/cs/project/GJ17-20357Y" target="_blank" >GJ17-20357Y: Paralely v adaptaci horských populací dvou druhů Arabidopsis</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2021

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Proceedings of the National Academy of Sciences of the United States of America

ISSN

0027-8424

e-ISSN

—

Svazek periodika

118

Číslo periodika v rámci svazku

21

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

10

Strana od-do

e2022713118

Kód UT WoS článku

000659439900015

EID výsledku v databázi Scopus

2-s2.0-85106386339