Interspecies variation in hominid gut microbiota controls host gene regulation

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F21%3A00554381" target="_blank" >RIV/60077344:_____/21:00554381 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/68081766:_____/21:00549092

Výsledek na webu

<a href="https://www.sciencedirect.com/science/article/pii/S2211124721015436" target="_blank" >https://www.sciencedirect.com/science/article/pii/S2211124721015436</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.celrep.2021.110057" target="_blank" >10.1016/j.celrep.2021.110057</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Interspecies variation in hominid gut microbiota controls host gene regulation

Popis výsledku v původním jazyce

The gut microbiome exhibits extreme compositional variation between hominid hosts. However, it is unclear how this variation impacts host physiology across species and whether this effect can be mediated through microbial regulation of host gene expression in interacting epithelial cells. Here, we characterize the transcriptional response of human colonic epithelial cells in vitro to live microbial communities extracted from humans, chimpanzees, gorillas, and orangutans. We find that most host genes exhibit a conserved response, whereby they respond similarly to the four hominid microbiomes. However, hundreds of host genes exhibit a divergent response, whereby they respond only to microbiomes from specific host species. Such genes are associated with intestinal diseases in humans, including inflammatory bowel disease and Crohn's disease. Last, we find that inflammation-associated microbial species regulate the expression of host genes previously associated with inflammatory bowel disease, suggesting health-related consequences for species-specific host-microbiome interactions across hominids.

Název v anglickém jazyce

Interspecies variation in hominid gut microbiota controls host gene regulation

Popis výsledku anglicky

The gut microbiome exhibits extreme compositional variation between hominid hosts. However, it is unclear how this variation impacts host physiology across species and whether this effect can be mediated through microbial regulation of host gene expression in interacting epithelial cells. Here, we characterize the transcriptional response of human colonic epithelial cells in vitro to live microbial communities extracted from humans, chimpanzees, gorillas, and orangutans. We find that most host genes exhibit a conserved response, whereby they respond similarly to the four hominid microbiomes. However, hundreds of host genes exhibit a divergent response, whereby they respond only to microbiomes from specific host species. Such genes are associated with intestinal diseases in humans, including inflammatory bowel disease and Crohn's disease. Last, we find that inflammation-associated microbial species regulate the expression of host genes previously associated with inflammatory bowel disease, suggesting health-related consequences for species-specific host-microbiome interactions across hominids.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10606 - Microbiology

Projekt

<a href="/cs/project/LH15175" target="_blank" >LH15175: Funkční interakce mezi genovou regulací hostitele a mikrobiotou v trávicím traktu primátů</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2021

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Cell Reports

ISSN

2211-1247

e-ISSN

2211-1247

Svazek periodika

37

Číslo periodika v rámci svazku

8

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

20

Strana od-do

110057

Kód UT WoS článku

000722835600002

EID výsledku v databázi Scopus

2-s2.0-85119507935