Baylisascaris transfuga (Ascaridoidea, Nematoda) from European brown bear (Ursus arctos) causing larva migrans in laboratory mice with clinical manifestation

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F22%3A00553057" target="_blank" >RIV/60077344:_____/22:00553057 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216224:14310/22:00128168 RIV/60460709:41210/22:92356 RIV/62157124:16170/22:43879898 RIV/60460709:41210/23:92351

Výsledek na webu

<a href="https://link.springer.com/article/10.1007/s00436-021-07417-z" target="_blank" >https://link.springer.com/article/10.1007/s00436-021-07417-z</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s00436-021-07417-z" target="_blank" >10.1007/s00436-021-07417-z</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Baylisascaris transfuga (Ascaridoidea, Nematoda) from European brown bear (Ursus arctos) causing larva migrans in laboratory mice with clinical manifestation

Popis výsledku v původním jazyce

Due to the recent recovery of brown bear populations in Central Europe, information about their ascarid parasite, Baylisascaris transfuga is necessary as the parasite represents a part of natural ecological networks. B. transfuga can lead to larva migrans syndrome in accidental hosts, but its zoonotic potential has not been confirmed. The resent study compares development of larva migrans in infected mice inoculated with two infectious doses (ID 200 and ID 2000) of B. transfuga embryonated eggs, and the clinical manifestation to evaluate the pathogenicity of the larvae. Histopathology revealed that the liver was the most severely infected organ. The moderately infected organs included lung, brain, skeletal muscles and jejunum and the less infected ones were the eyes, heart, kidneys and spleen. The high pathogenicity of B. transfuga to mice was reflected in high mortality (33,3%) after infection, with mortality increasing with higher infectious dose. The results extend the knowledge of the interaction of B. transfuga and its aberrant hosts and contribute to the understanding of the epidemiology and transmission of this bears roundworm.

Název v anglickém jazyce

Baylisascaris transfuga (Ascaridoidea, Nematoda) from European brown bear (Ursus arctos) causing larva migrans in laboratory mice with clinical manifestation

Popis výsledku anglicky

Due to the recent recovery of brown bear populations in Central Europe, information about their ascarid parasite, Baylisascaris transfuga is necessary as the parasite represents a part of natural ecological networks. B. transfuga can lead to larva migrans syndrome in accidental hosts, but its zoonotic potential has not been confirmed. The resent study compares development of larva migrans in infected mice inoculated with two infectious doses (ID 200 and ID 2000) of B. transfuga embryonated eggs, and the clinical manifestation to evaluate the pathogenicity of the larvae. Histopathology revealed that the liver was the most severely infected organ. The moderately infected organs included lung, brain, skeletal muscles and jejunum and the less infected ones were the eyes, heart, kidneys and spleen. The high pathogenicity of B. transfuga to mice was reflected in high mortality (33,3%) after infection, with mortality increasing with higher infectious dose. The results extend the knowledge of the interaction of B. transfuga and its aberrant hosts and contribute to the understanding of the epidemiology and transmission of this bears roundworm.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30310 - Parasitology

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2022

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Parasitology Research

ISSN

0932-0113

e-ISSN

1432-1955

Svazek periodika

121

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

12

Strana od-do

645-651

Kód UT WoS článku

000738437100003

EID výsledku v databázi Scopus

2-s2.0-85122328480