Polycomb Repressive Complex 2 in Eukaryotes-An Evolutionary Perspective

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F22%3A00559983" target="_blank" >RIV/60077344:_____/22:00559983 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/60076658:12310/22:43904857

Výsledek na webu

<a href="https://www.mdpi.com/2075-4655/6/1/3" target="_blank" >https://www.mdpi.com/2075-4655/6/1/3</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/epigenomes6010003" target="_blank" >10.3390/epigenomes6010003</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Polycomb Repressive Complex 2 in Eukaryotes-An Evolutionary Perspective

Popis výsledku v původním jazyce

Polycomb repressive complex 2 (PRC2) represents a group of evolutionarily conserved multi-subunit complexes that repress gene transcription by introducing trimethylation of lysine 27 on histone 3 (H3K27me3). PRC2 activity is of key importance for cell identity specification and developmental phase transitions in animals and plants. The composition, biochemistry, and developmental function of PRC2 in animal and flowering plant model species are relatively well described. Recent evidence demonstrates the presence of PRC2 complexes in various eukaryotic supergroups, suggesting conservation of the complex and its function. Here, we provide an overview of the current understanding of PRC2-mediated repression in different representatives of eukaryotic supergroups with a focus on the green lineage. By comparison of PRC2 in different eukaryotes, we highlight the possible common and diverged features suggesting evolutionary implications and outline emerging questions and directions for future research of polycomb repression and its evolution.

Název v anglickém jazyce

Polycomb Repressive Complex 2 in Eukaryotes-An Evolutionary Perspective

Popis výsledku anglicky

Polycomb repressive complex 2 (PRC2) represents a group of evolutionarily conserved multi-subunit complexes that repress gene transcription by introducing trimethylation of lysine 27 on histone 3 (H3K27me3). PRC2 activity is of key importance for cell identity specification and developmental phase transitions in animals and plants. The composition, biochemistry, and developmental function of PRC2 in animal and flowering plant model species are relatively well described. Recent evidence demonstrates the presence of PRC2 complexes in various eukaryotic supergroups, suggesting conservation of the complex and its function. Here, we provide an overview of the current understanding of PRC2-mediated repression in different representatives of eukaryotic supergroups with a focus on the green lineage. By comparison of PRC2 in different eukaryotes, we highlight the possible common and diverged features suggesting evolutionary implications and outline emerging questions and directions for future research of polycomb repression and its evolution.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10602 - Biology (theoretical, mathematical, thermal, cryobiology, biological rhythm), Evolutionary biology

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2022

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Epigenomes

ISSN

2075-4655

e-ISSN

2075-4655

Svazek periodika

6

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

CH - Švýcarská konfederace

Počet stran výsledku

29

Strana od-do

3

Kód UT WoS článku

000775429600001

EID výsledku v databázi Scopus

2-s2.0-85123806373