Molecular farming: Expanding the field of edible vaccines for sustainable fish aquaculture

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F22%3A00561339" target="_blank" >RIV/60077344:_____/22:00561339 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/60076658:12520/22:43904609 RIV/61989592:15640/22:73618637

Výsledek na webu

<a href="https://onlinelibrary.wiley.com/doi/10.1111/raq.12683" target="_blank" >https://onlinelibrary.wiley.com/doi/10.1111/raq.12683</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1111/raq.12683" target="_blank" >10.1111/raq.12683</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Molecular farming: Expanding the field of edible vaccines for sustainable fish aquaculture

Popis výsledku v původním jazyce

Vaccines represent one of the most promising strategies for mitigating economic losses imposed by infectious diseases to global aquaculture. While the majority of commercial vaccines employ injection as the main route of delivery, a substantial body of research explores other avenues for the stimulation of protective immunity. Oral vaccines, representing the most favourable and convenient solution for the aquaculture industry, have been at the forefront of scientific interest for the last couple of decades. The orchestrated effort resulted in identifying the main roadblocks on the path to an ideal edible vaccine and provided several ingenious solutions improving the activation of immunity, ensuring the stability of administered antigens and their uptake upon the passage through the stomach. In the presented review, we describe advances in the available knowledge of the processes prerequisite for developing protective mucosal vaccines and focus readers' attention on the untapped potential of plant-based production systems in this effort. We propose that these approaches not only meet production demands but also fulfil all requirements of an oral vaccine, addressing all the obstacles, previously solved via separate strategies, in one platform. Thus, combined with the available knowledge of molecular adjuvants and produced for a fraction of the cost, plant-based production, so-called molecular farming, is an ideal candidate for vaccine development, paving the road to sustainable aquaculture.

Název v anglickém jazyce

Molecular farming: Expanding the field of edible vaccines for sustainable fish aquaculture

Popis výsledku anglicky

Vaccines represent one of the most promising strategies for mitigating economic losses imposed by infectious diseases to global aquaculture. While the majority of commercial vaccines employ injection as the main route of delivery, a substantial body of research explores other avenues for the stimulation of protective immunity. Oral vaccines, representing the most favourable and convenient solution for the aquaculture industry, have been at the forefront of scientific interest for the last couple of decades. The orchestrated effort resulted in identifying the main roadblocks on the path to an ideal edible vaccine and provided several ingenious solutions improving the activation of immunity, ensuring the stability of administered antigens and their uptake upon the passage through the stomach. In the presented review, we describe advances in the available knowledge of the processes prerequisite for developing protective mucosal vaccines and focus readers' attention on the untapped potential of plant-based production systems in this effort. We propose that these approaches not only meet production demands but also fulfil all requirements of an oral vaccine, addressing all the obstacles, previously solved via separate strategies, in one platform. Thus, combined with the available knowledge of molecular adjuvants and produced for a fraction of the cost, plant-based production, so-called molecular farming, is an ideal candidate for vaccine development, paving the road to sustainable aquaculture.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

40103 - Fishery

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2022

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Reviews in Aquaculture

ISSN

1753-5123

e-ISSN

1753-5131

Svazek periodika

14

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

24

Strana od-do

1978-2001

Kód UT WoS článku

000794168100001

EID výsledku v databázi Scopus

2-s2.0-85128977804