Animal models of tick-borne encephalitis for preclinical antiviral research

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F22%3A00569216" target="_blank" >RIV/60077344:_____/22:00569216 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00027162:_____/22:N0000248 RIV/00216224:14310/22:00130085

Výsledek na webu

<a href="https://www.sciencedirect.com/science/article/abs/pii/S0065774322000021?pes=vor" target="_blank" >https://www.sciencedirect.com/science/article/abs/pii/S0065774322000021?pes=vor</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/bs.armc.2022.08.002" target="_blank" >10.1016/bs.armc.2022.08.002</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Animal models of tick-borne encephalitis for preclinical antiviral research

Popis výsledku v původním jazyce

Tick-borne encephalitis (TBE), a central nervous system infection caused by the TBE virus (TBEV), is a public health concern in large, forested areas of Europe and Asia. The disease can manifest as a mild, febrile, flu-like illness, but it can also progress to meningitis, encephalitis, or meningoencephalitis. Myelitis and spinal paralysis may also occur. To date, there is no specific drug approved for the treatment of TBE. An essential prerequisite for the development of new specific therapies for TBE is the availability of suitable animal models for TBE. There are several animal models for TBE that include laboratory mice, rats, and nonhuman primates. None of these existing models is ideal for recapitulating all aspects of TBE in humans. Nevertheless, they are useful for studying different aspects of TBE pathogenesis and for testing and developing new therapeutic countermeasures.

Název v anglickém jazyce

Animal models of tick-borne encephalitis for preclinical antiviral research

Popis výsledku anglicky

Tick-borne encephalitis (TBE), a central nervous system infection caused by the TBE virus (TBEV), is a public health concern in large, forested areas of Europe and Asia. The disease can manifest as a mild, febrile, flu-like illness, but it can also progress to meningitis, encephalitis, or meningoencephalitis. Myelitis and spinal paralysis may also occur. To date, there is no specific drug approved for the treatment of TBE. An essential prerequisite for the development of new specific therapies for TBE is the availability of suitable animal models for TBE. There are several animal models for TBE that include laboratory mice, rats, and nonhuman primates. None of these existing models is ideal for recapitulating all aspects of TBE in humans. Nevertheless, they are useful for studying different aspects of TBE pathogenesis and for testing and developing new therapeutic countermeasures.

Druh

C - Kapitola v odborné knize

CEP obor

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OECD FORD obor

30310 - Parasitology

Projekt

<a href="/cs/project/NV19-05-00457" target="_blank" >NV19-05-00457: Genetický základ klinického obrazu a závažnosti klíšťové encefalitidy</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2022

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název knihy nebo sborníku

Annual Reports in Medicinal Chemistry

ISBN

978-0-323-98893-3

Počet stran výsledku

14

Strana od-do

243-256

Počet stran knihy

256

Název nakladatele

Elsevier

Místo vydání

Cambridge

Kód UT WoS kapitoly

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