Evolution of proteins involved in the final steps of juvenile hormone synthesis

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F23%3A00567899" target="_blank" >RIV/60077344:_____/23:00567899 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/60076658:12310/23:43906541

Výsledek na webu

<a href="https://www.sciencedirect.com/science/article/pii/S0022191023000136/pdfft?md5=bec717a693baa43cc75fb04d6a1e3cc5&pid=1-s2.0-S0022191023000136-main.pdf" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0022191023000136/pdfft?md5=bec717a693baa43cc75fb04d6a1e3cc5&pid=1-s2.0-S0022191023000136-main.pdf</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.jinsphys.2023.104487" target="_blank" >10.1016/j.jinsphys.2023.104487</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Evolution of proteins involved in the final steps of juvenile hormone synthesis

Popis výsledku v původním jazyce

Juvenile hormone (JH), a sesquiterpenoid produced by the insect corpus allatum gland (CA), is a key regulator of insect metamorphosis, reproduction, caste differentiation, and polyphenism. The first part of JH biosynthesis occurs via the universal eukaryotic mevalonate pathway. The final steps involve epoxidation and methylation. However, the sequence of these steps might not be conserved among all insects and Crustacea. Therefore, we used available genomic and transcriptomic data and identified JH acid methyltransferase (JHAMT), analyzed their genomic duplications in selected model organisms, and reconstructed their phylogeny. We have further reconstructed phylogeny of FAMeT proteins and show that evolution of this protein group is more complicated than originally appreciated. The analysis delineates important milestones in the evolution of several JH biosynthetic enzymes in arthropods, reviews major literature data on the last steps of JH synthesis, and defines questions and some hypotheses worth pursuing experimentally.

Název v anglickém jazyce

Evolution of proteins involved in the final steps of juvenile hormone synthesis

Popis výsledku anglicky

Juvenile hormone (JH), a sesquiterpenoid produced by the insect corpus allatum gland (CA), is a key regulator of insect metamorphosis, reproduction, caste differentiation, and polyphenism. The first part of JH biosynthesis occurs via the universal eukaryotic mevalonate pathway. The final steps involve epoxidation and methylation. However, the sequence of these steps might not be conserved among all insects and Crustacea. Therefore, we used available genomic and transcriptomic data and identified JH acid methyltransferase (JHAMT), analyzed their genomic duplications in selected model organisms, and reconstructed their phylogeny. We have further reconstructed phylogeny of FAMeT proteins and show that evolution of this protein group is more complicated than originally appreciated. The analysis delineates important milestones in the evolution of several JH biosynthetic enzymes in arthropods, reviews major literature data on the last steps of JH synthesis, and defines questions and some hypotheses worth pursuing experimentally.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10605 - Developmental biology

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2023

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Insect Physiology

ISSN

0022-1910

e-ISSN

1879-1611

Svazek periodika

145

Číslo periodika v rámci svazku

MAR 01

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

12

Strana od-do

104487

Kód UT WoS článku

000965068800001

EID výsledku v databázi Scopus

2-s2.0-85147571568