Molecular Mechanism of the Circadian Clock

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F23%3A00571397" target="_blank" >RIV/60077344:_____/23:00571397 - isvavai.cz</a>

Výsledek na webu

<a href="https://link.springer.com/chapter/10.1007/978-981-99-0726-7_4" target="_blank" >https://link.springer.com/chapter/10.1007/978-981-99-0726-7_4</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/978-981-99-0726-7_4" target="_blank" >10.1007/978-981-99-0726-7_4</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Molecular Mechanism of the Circadian Clock

Popis výsledku v původním jazyce

Nearly all organisms possess a circadian clock, a genetically determined device that generates endogenous oscillations with a period of approximately 24 h. From a molecular perspective, the circadian clock relies on negative transcription-translation feedback loops. In insects, the molecular and genetic basis of the circadian clock machinery has been revealed by the remarkable genetic tools available to the fruit fly Drosophila melanogaster. However, the dawn of reverse genetics methods applicable to nonmodel species has led to recent significant advances in our understanding of the circadian clock beyond Drosophila. To illustrate the molecular mechanism behind the insect circadian clock, the first section focuses primarily on Drosophila melanogaster as the best established and most detailed insect model. Conserved components of the insect clocks are then identified at the genetic level, and lineage-specific idiosyncrasies and variations in setup are highlighted and further discussed. Functional evidence from non-Drosophila insects is reviewed, and the main descriptive data from molecular biology are presented in an evolutionary context and briefly summarized.

Název v anglickém jazyce

Molecular Mechanism of the Circadian Clock

Popis výsledku anglicky

Nearly all organisms possess a circadian clock, a genetically determined device that generates endogenous oscillations with a period of approximately 24 h. From a molecular perspective, the circadian clock relies on negative transcription-translation feedback loops. In insects, the molecular and genetic basis of the circadian clock machinery has been revealed by the remarkable genetic tools available to the fruit fly Drosophila melanogaster. However, the dawn of reverse genetics methods applicable to nonmodel species has led to recent significant advances in our understanding of the circadian clock beyond Drosophila. To illustrate the molecular mechanism behind the insect circadian clock, the first section focuses primarily on Drosophila melanogaster as the best established and most detailed insect model. Conserved components of the insect clocks are then identified at the genetic level, and lineage-specific idiosyncrasies and variations in setup are highlighted and further discussed. Functional evidence from non-Drosophila insects is reviewed, and the main descriptive data from molecular biology are presented in an evolutionary context and briefly summarized.

Druh

C - Kapitola v odborné knize

CEP obor

—

OECD FORD obor

10605 - Developmental biology

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2023

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název knihy nebo sborníku

Insect Chronobiology

ISBN

978-981-99-0725-0

Počet stran výsledku

36

Strana od-do

49-84

Počet stran knihy

357

Název nakladatele

Springer

Místo vydání

Singapore

Kód UT WoS kapitoly

—